ALBERT

Description: Abstract 5055 Background: Myelodysplastic syndrome (MDS) represents a heterogenous disorder characterized by ineffective hematopoiesis and propensity to evolution to acute myelogenous leukemia (AML). Azanucleosides like 5-azacitidine (AZA) and decitabine-5-aza-2'-deoxycytidine (DAC) improve survival (Fenaux, 2008; Silverman, 2002 and Steensma, 2009). In this retrospective study, we aimed to evaluate: (1) clinical outcomes in Veterans (pts) diagnosed with MDS and treated with either 5-AZA or DAC and (2) survival outcomes according to number of cycles received of either hypomethylating agent. Design: After obtaining IRB approval, data was collected from the Michael E. DeBakey VA Medical Center cancer registry and pharmacy records between January 1, 2000 and June 1, 2011. For analysis, pts were included in the study if they were ≥18 years (y), had morphological evidence of MDS per bone marrow examination at the time of diagnosis and were treated with either hypomethylating agent (but not both) as first-line therapy for 2 cycles or more. Pts with de-novo AML prior to treatment were excluded. Pts received AZA at 75 mg/m2/day (d) (dose range, 50–75 mg/m2/d) (d 1–7) or DAC at 20 mg/m2/d (dose range, 15–20 mg/m2/d) (d1-5) at four weeks interval. The primary end-point was Overall Response Rate (ORR) which included Complete Response (CR), Partial Response (PR) and Hematological Improvement (HI) according to IWG 2006. Secondary end-point was Overall Survival (OS) per treatment group. Results: We identified 39 pts who underwent treatment with azanucleosides. 18 pts were excluded either because of de-novo AML diagnosis at presentation, they had received 〈 2 cycles of treatment, or had received 〉 2 cycles of both agents, 11, 5, and 2 pts, respectively. Demographics are depicted in table 1. 21 pts were available for analysis, from which 2/21 (10%) and 19/21 (90%) were female and male, respectively. Median age was 66 y (range, 55–78 y) and 63 y (range, 56–78 y) for pts treated with AZA vs. DAC (P=0.458). 9/21 (43%), 5/21 (24%), 7/21 (33%) pts had good, intermediate and poor-risk karyotypes. 13/21 (62%) and 8/21 (38%) pts received AZA and DAC, respectively. ORR was 15% vs. 38%, for AZA vs. DAC (P=0.618). Per IPSS score, 52% and 48 % of the pts were high-risk (high and Int-2) and low-risk (Int-1 and low), respectively. ORR was 30% vs. 18%, for low-risk vs. high-risk pts (P=0.635). OS was superior in low-risk compared to high-risk pts (394d vs. 214d, P=0.029, Figure 1). Pts who responded to therapy (CR+ PR +HI), had superior OS compared to pts with stable or progressive disease (411d vs. 194d, P= 0.01). There was no statistical difference in OS between different age groups. OS in pts receiving ≥4 or