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  • 1
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    Arabidopsis type I metacaspases control cell death (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-11-26
    Description: Metacaspases are distant relatives of animal caspases found in protozoa, fungi, and plants. Limited experimental data exist defining their function(s), despite their discovery by homology modeling a decade ago. We demonstrated that two type I metacaspases, AtMC1 and AtMC2, antagonistically control programmed cell death in Arabidopsis. AtMC1 is a positive regulator of cell death and requires conserved caspase-like putative catalytic residues for its function. AtMC2 negatively regulates cell death. This function is independent of the putative catalytic residues. Manipulation of the Arabidopsis type I metacaspase regulatory module can nearly eliminate the hypersensitive cell death response (HR) activated by plant intracellular immune receptors. This does not lead to enhanced pathogen proliferation, decoupling HR from restriction of pathogen growth.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Coll, Nuria S -- Vercammen, Dominique -- Smidler, Andrea -- Clover, Charles -- Van Breusegem, Frank -- Dangl, Jeffery L -- Epple, Petra -- R01 GM057171/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2010 Dec 3;330(6009):1393-7. doi: 10.1126/science.1194980. Epub 2010 Nov 18.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, 108 Coker Hall, University of North Carolina (UNC), CB 3280, Chapel Hill, NC 27599-3280, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21097903" target="_blank"〉PubMed〈/a〉
    Keywords: *Apoptosis ; Arabidopsis/*enzymology/immunology/microbiology/*physiology ; Arabidopsis Proteins/chemistry/genetics/*metabolism ; Caspases/chemistry/genetics/*metabolism ; DNA-Binding Proteins/chemistry/genetics/metabolism ; Mutation ; Oomycetes/physiology ; Plant Diseases/immunology/microbiology ; Plants, Genetically Modified ; Pseudomonas syringae/physiology ; Transcription Factors/chemistry/genetics/metabolism ; Zinc Fingers
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Biotechnology. Regulating gene drives (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-07-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Oye, Kenneth A -- Esvelt, Kevin -- Appleton, Evan -- Catteruccia, Flaminia -- Church, George -- Kuiken, Todd -- Lightfoot, Shlomiya Bar-Yam -- McNamara, Julie -- Smidler, Andrea -- Collins, James P -- New York, N.Y. -- Science. 2014 Aug 8;345(6197):626-8. doi: 10.1126/science.1254287. Epub 2014 Jul 17.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Political Science Department, Massachusetts Institute of Technology. Engineering Systems Division, Massachusetts Institute of Technology. oye@mit.edu. ; Wyss Institute, Harvard University. ; Bioinformatics, Boston University. ; Harvard School of Public Health. University of Perugia, Italy. ; Woodrow Wilson International Center for Scholars. ; Engineering Systems Division, Massachusetts Institute of Technology. ; Harvard School of Public Health. Harvard Medical School. ; School of Life Sciences, Arizona State University.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25035410" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Genetically Modified/*genetics ; Caspase 9/genetics ; *Clustered Regularly Interspaced Short Palindromic Repeats ; Communicable Disease Control/*methods ; Culicidae/*genetics ; Dengue/prevention & control ; *Gene Expression Regulation ; Gene Targeting/methods ; Genetic Engineering/*methods ; Humans ; Malaria/parasitology/prevention & control ; Mosquito Control/*methods ; RNA/genetics ; Reproduction/genetics ; Risk Management
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Tools for Anopheles gambiae Transgenesis (2015)
    Genetics Society of America (GSA)
    Details
    Publication Date: 2015-06-12
    Description: Transgenesis is an essential tool to investigate gene function and to introduce desired characters in laboratory organisms. Setting-up transgenesis in non-model organisms is challenging due to the diversity of biological life traits and due to knowledge gaps in genomic information. Some procedures will be broadly applicable to many organisms, and others have to be specifically developed for the target species. Transgenesis in disease vector mosquitoes has existed since the 2000s but has remained limited by the delicate biology of these insects. Here, we report a compilation of the transgenesis tools that we have designed for the malaria vector Anopheles gambiae , including new docking strains, convenient transgenesis plasmids, a puromycin resistance selection marker, mosquitoes expressing cre recombinase, and various reporter lines defining the activity of cloned promoters. This toolbox contributed to rendering transgenesis routine in this species and is now enabling the development of increasingly refined genetic manipulations such as targeted mutagenesis. Some of the reagents and procedures reported here are easily transferable to other nonmodel species, including other disease vector or agricultural pest insects.
    Electronic ISSN: 2160-1836
    Topics: Biology
    Published by Genetics Society of America (GSA)
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  • 4
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    The plant metacaspase AtMC1 in pathogen-triggered programmed cell death and aging: functional linkage with autophagy (2014)
    Springer Nature
    Details
    Publication Date: 2014-05-02
    Print ISSN: 1350-9047
    Electronic ISSN: 1476-5403
    Topics: Biology , Medicine
    Published by Springer Nature
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