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  • 1
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    Transport mechanism through metal-cobaltite interfaces (2016)
    American Institute of Physics (AIP)
    Details
    Publication Date: 2016-07-06
    Description: The resistive switching (RS) properties as a function of temperature were studied for Ag/La 1− x Sr x CoO 3 (LSCO) interfaces. The LSCO is a fully relaxed 100 nm film grown by metal organic deposition on a LaAlO 3 substrate. Both low and a high resistance states were set at room temperature, and the temperature dependence of their current-voltage (IV) characteristics was measured taking care to avoid a significant change of the resistance state. The obtained non-trivial IV curves of each state were well reproduced by a circuit model which includes a Poole-Frenkel element and two ohmic resistances. A microscopic description of the changes produced by the RS is given, which enables to envision a picture of the interface as an area where conductive and insulating phases are mixed, producing Maxwell-Wagner contributions to the dielectric properties.
    Print ISSN: 0003-6951
    Electronic ISSN: 1077-3118
    Topics: Physics
    Published by American Institute of Physics (AIP)
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  • 2
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    N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-09-24
    Description: Although many eukaryotic proteins are amino (N)-terminally acetylated, structural mechanisms by which N-terminal acetylation mediates protein interactions are largely unknown. Here, we found that N-terminal acetylation of the E2 enzyme, Ubc12, dictates distinctive E3-dependent ligation of the ubiquitin-like protein Nedd8 to Cul1. Structural, biochemical, biophysical, and genetic analyses revealed how complete burial of Ubc12's N-acetyl-methionine in a hydrophobic pocket in the E3, Dcn1, promotes cullin neddylation. The results suggest that the N-terminal acetyl both directs Ubc12's interactions with Dcn1 and prevents repulsion of a charged N terminus. Our data provide a link between acetylation and ubiquitin-like protein conjugation and define a mechanism for N-terminal acetylation-dependent recognition.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3214010/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3214010/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Scott, Daniel C -- Monda, Julie K -- Bennett, Eric J -- Harper, J Wade -- Schulman, Brenda A -- P30 CA021765/CA/NCI NIH HHS/ -- P30 CA021765-33/CA/NCI NIH HHS/ -- R01 GM054137/GM/NIGMS NIH HHS/ -- R01 GM054137-13/GM/NIGMS NIH HHS/ -- R01 GM069530/GM/NIGMS NIH HHS/ -- R01 GM069530-10/GM/NIGMS NIH HHS/ -- R01 GM070565/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2011 Nov 4;334(6056):674-8. doi: 10.1126/science.1209307. Epub 2011 Sep 22.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Structural Biology Department, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21940857" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylation ; Amino Acid Sequence ; Cullin Proteins/metabolism ; Humans ; Molecular Sequence Data ; Multiprotein Complexes/*metabolism ; Protein Binding ; Saccharomyces cerevisiae Proteins/*metabolism ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitins/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Structural biology: Transformative encounters (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-02-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schulman, Brenda A -- Haas, Arthur L -- R01 GM069530/GM/NIGMS NIH HHS/ -- R01 GM077053/GM/NIGMS NIH HHS/ -- England -- Nature. 2010 Feb 18;463(7283):889-90. doi: 10.1038/463889a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20164915" target="_blank"〉PubMed〈/a〉
    Keywords: Crystallography, X-Ray ; Protein Conformation ; SUMO-1 Protein/*chemistry/*metabolism ; Ubiquitin-Activating Enzymes/*chemistry/*metabolism ; Ubiquitin-Conjugating Enzymes/metabolism ; Ubiquitins/chemistry/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 4
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    A physical, genetic and functional sequence assembly of the barley genome (2012)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2012-10-19
    Description: Barley (Hordeum vulgare L.) is among the world's earliest domesticated and most important crop plants. It is diploid with a large haploid genome of 5.1 gigabases (Gb). Here we present an integrated and ordered physical, genetic and functional sequence resource that describes the barley gene-space in a structured whole-genome context. We developed a physical map of 4.98 Gb, with more than 3.90 Gb anchored to a high-resolution genetic map. Projecting a deep whole-genome shotgun assembly, complementary DNA and deep RNA sequence data onto this framework supports 79,379 transcript clusters, including 26,159 'high-confidence' genes with homology support from other plant genomes. Abundant alternative splicing, premature termination codons and novel transcriptionally active regions suggest that post-transcriptional processing forms an important regulatory layer. Survey sequences from diverse accessions reveal a landscape of extensive single-nucleotide variation. Our data provide a platform for both genome-assisted research and enabling contemporary crop improvement.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉International Barley Genome Sequencing Consortium -- Mayer, Klaus F X -- Waugh, Robbie -- Brown, John W S -- Schulman, Alan -- Langridge, Peter -- Platzer, Matthias -- Fincher, Geoffrey B -- Muehlbauer, Gary J -- Sato, Kazuhiro -- Close, Timothy J -- Wise, Roger P -- Stein, Nils -- BB/100663X/1/Biotechnology and Biological Sciences Research Council/United Kingdom -- England -- Nature. 2012 Nov 29;491(7426):711-6. doi: 10.1038/nature11543. Epub 2012 Oct 17.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23075845" target="_blank"〉PubMed〈/a〉
    Keywords: Alternative Splicing/genetics ; Codon, Nonsense/genetics ; Crops, Agricultural/genetics ; Evolution, Molecular ; Gene Expression Regulation, Plant ; Genes, Plant/genetics ; Genome, Plant/*genetics ; Genomics ; Hordeum/classification/*genetics ; Molecular Sequence Annotation ; Physical Chromosome Mapping ; Polymorphism, Single Nucleotide/genetics ; Repetitive Sequences, Nucleic Acid/genetics ; *Sequence Analysis, DNA ; Transcriptome/genetics
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 5
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    Structural biology: A protein engagement RING (2012)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2012-09-08
    Description: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665766/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665766/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lima, Christopher D -- Schulman, Brenda A -- R01 GM065872/GM/NIGMS NIH HHS/ -- R01 GM069530/GM/NIGMS NIH HHS/ -- R01 GM077053/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2012 Sep 6;489(7414):43-4. doi: 10.1038/489043a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22955611" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biocatalysis ; Humans ; Nuclear Proteins/*chemistry ; Transcription Factors/*chemistry ; Ubiquitin/*metabolism ; Ubiquitin-Conjugating Enzymes/*chemistry/*metabolism ; Ubiquitin-Protein Ligases/*chemistry ; *Zinc Fingers
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 6
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    Medicine. A portfolio model of drug development for tuberculosis (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-03-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Glickman, Seth W -- Rasiel, Emma B -- Hamilton, Carol Dukes -- Kubataev, Arsen -- Schulman, Kevin A -- New York, N.Y. -- Science. 2006 Mar 3;311(5765):1246-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Health Sector Management Program, Fuqua School of Business, Duke University, Durham, NC 27708, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16513969" target="_blank"〉PubMed〈/a〉
    Keywords: Antitubercular Agents/*therapeutic use ; Clinical Trials as Topic/economics ; Computer Simulation ; Costs and Cost Analysis ; *Drug Approval/economics ; Drug Evaluation, Preclinical/economics ; Drug Industry ; Humans ; Monte Carlo Method ; National Institutes of Health (U.S.) ; Private Sector ; Probability ; Public Sector ; Time Factors ; Tuberculosis/*drug therapy ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Anomalous time relaxation of the nonvolatile resistive state in bipolar resistive-switching oxide-based memories (2012)
    American Physical Society (APS)
    Details
    Publication Date: 2012-09-19
    Description: Author(s): A. Schulman, M. J. Rozenberg, and C. Acha We have studied long time relaxation effects on the nonvolatile resistance state produced by resistive switching in devices composed by ceramic YBa 2 Cu 3 O 7− δ and La 0.7 Sr 0.3 MnO 3 /metal (Au, Pt, Ag) interfaces. The time relaxation can be described by a stretched exponential law that is characterized by a... [Phys. Rev. B 86, 104426] Published Tue Sep 18, 2012
    Keywords: Magnetism
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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  • 8
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    [ASAP] Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation (2018)
    American Chemical Society (ACS)
    Details
    Publication Date: 2018-03-28
    Description: Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.7b01277
    Topics: Chemistry and Pharmacology
    Published by American Chemical Society (ACS)
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  • 9
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    [ASAP] Discovery of an Orally Bioavailable Inhibitor of Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation (2018)
    American Chemical Society (ACS)
    Details
    Publication Date: 2018-03-28
    Description: Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.7b01282
    Topics: Chemistry and Pharmacology
    Published by American Chemical Society (ACS)
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  • 10
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    Poole-Frenkel effect and variable-range hopping conduction in metal/YBCO resistive switching devices (2015)
    American Institute of Physics (AIP)
    Details
    Publication Date: 2015-08-01
    Description: Current-voltage (IV) characteristics and the temperature dependence of the contact resistance [ R ( T )] of Au/YBa 2 Cu 3 O 7− δ (optimally doped YBCO) interfaces have been studied at different resistance states. These states were produced by resistive switching after accumulating cyclic electrical pulses of increasing number and voltage amplitude. The IV characteristics and the R ( T ) dependence of the different states are consistent with a Poole-Frenkel (P-F) emission mechanism with trapping-energy levels E t in the 0.06–0.11 eV range. E t remains constant up to a number-of-pulses-dependent critical voltage and increases linearly with a further increase in the voltage amplitude of the pulses. The observation of a P-F mechanism reveals the existence of an oxygen-depleted layer of YBCO near the interface. A simple electrical transport scenario is discussed, where the degree of disorder, the trap energy level, and the temperature range determine an electrical conduction dominated by non-linear effects, either in a P-F emission or in a variable-range hopping regime.
    Print ISSN: 0021-8979
    Electronic ISSN: 1089-7550
    Topics: Physics
    Published by American Institute of Physics (AIP)
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