Publication Date:
2007-05-19
Description:
Muller et al. (Reports, 27 October 2006, p. 654) showed that inhibition of the gamma-tubulin ring complex (gamma-TuRC) activates the spindle assembly checkpoint (SAC), which led them to suggest that gamma-TuRC proteins play molecular roles in SAC activation. Because gamma-TuRC inhibition leads to pleiotropic spindle defects, which are well known to activate kinetochore-derived checkpoint signaling, we believe that this conclusion is premature.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2590763/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2590763/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Taylor, Stephen S -- Hardwick, Kevin G -- Sawin, Kenneth E -- Biggins, Sue -- Piatti, Simonetta -- Khodjakov, Alexey -- Rieder, Conly L -- Salmon, Edward D -- Musacchio, Andrea -- R01 GM059363/GM/NIGMS NIH HHS/ -- R01 GM059363-09/GM/NIGMS NIH HHS/ -- R37 GM040198/GM/NIGMS NIH HHS/ -- R37 GM040198-23/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2007 May 18;316(5827):982; author reply 982.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Faculty of Life Sciences, University of Manchester, Manchester, UK. stephen.taylor@manchester.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17510347" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Centrosome/physiology
;
Kinetochores/*physiology
;
Microtubule-Associated Proteins/antagonists & inhibitors/*metabolism
;
Microtubules/*metabolism/ultrastructure
;
*Mitosis
;
Signal Transduction
;
Spindle Apparatus/*metabolism
;
Tubulin/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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