Publication Date:
1994-05-20
Description:
When the landmark patient Phineas Gage died in 1861, no autopsy was performed, but his skull was later recovered. The brain lesion that caused the profound personality changes for which his case became famous has been presumed to have involved the left frontal region, but questions have been raised about the involvement of other regions and about the exact placement of the lesion within the vast frontal territory. Measurements from Gage's skull and modern neuroimaging techniques were used to reconstitute the accident and determine the probable location of the lesion. The damage involved both left and right prefrontal cortices in a pattern that, as confirmed by Gage's modern counterparts, causes a defect in rational decision making and the processing of emotion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Damasio, H -- Grabowski, T -- Frank, R -- Galaburda, A M -- Damasio, A R -- P01 NS19632/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1994 May 20;264(5162):1102-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurology, University of Iowa Hospitals & Clinics, Iowa City 52242.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8178168" target="_blank"〉PubMed〈/a〉
Keywords:
Accidents, Occupational
;
Brain Injuries/history/*psychology
;
*Decision Making
;
*Emotions
;
Explosions
;
History, 19th Century
;
Humans
;
Image Processing, Computer-Assisted
;
Male
;
Prefrontal Cortex/*injuries/physiology
;
Skull/*injuries
;
Wounds, Penetrating/history/*psychology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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