Publication Date:
2005-01-22
Description:
Planar cell polarity (PCP) signaling generates subcellular asymmetry along an axis orthogonal to the epithelial apical-basal axis. Through a poorly understood mechanism, cell clones that have mutations in some PCP signaling components, including some, but not all, alleles of the receptor frizzled, cause polarity disruptions of neighboring wild-type cells, a phenomenon referred to as domineering nonautonomy. Here, a contact-dependent signaling hypothesis, derived from experimental results, is shown by reaction-diffusion, partial differential equation modeling and simulation to fully reproduce PCP phenotypes, including domineering nonautonomy, in the Drosophila wing. The sufficiency of this model and the experimental validation of model predictions reveal how specific protein-protein interactions produce autonomy or domineering nonautonomy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Amonlirdviman, Keith -- Khare, Narmada A -- Tree, David R P -- Chen, Wei-Shen -- Axelrod, Jeffrey D -- Tomlin, Claire J -- R01-GM59823/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2005 Jan 21;307(5708):423-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Aeronautics and Astronautics, Stanford University, Stanford, CA 94305-4035, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15662015" target="_blank"〉PubMed〈/a〉
Keywords:
Adaptor Proteins, Signal Transducing
;
Alleles
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Animals
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Cell Membrane/metabolism
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*Cell Polarity
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Diffusion
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Drosophila/*cytology/genetics/metabolism
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Drosophila Proteins/genetics/metabolism
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Feedback, Physiological
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Frizzled Receptors
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Mathematics
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Membrane Proteins/genetics/metabolism
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*Models, Biological
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Mutation
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Phenotype
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Phosphoproteins/genetics/metabolism
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Protein Binding
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Receptors, G-Protein-Coupled
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*Signal Transduction
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Wings, Animal/*cytology/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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