Publication Date:
1996-11-29
Description:
Progression to acquired immunodeficiency syndrome (AIDS) has been related to exhaustion of the regenerative capacity of the immune system resulting from high T cell turnover. Analysis of telomeric terminal restriction fragment (TRF) length, a marker for cellular replicative history, showed that CD8(+) T cell TRF length decreased but CD4(+) T cell TRF length was stable during the course of human immunodeficiency virus type-1 (HIV-1) infection, which was not explained by differential telomerase activity. This observation provides evidence that turnover in the course of HIV-1 infection can be increased considerably in CD8(+) T cells, but not in CD4(+) T cells. These results are compatible with CD4(+) T cell decline in HIV-1 infection caused by interference with cell renewal.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wolthers, K C -- Bea, G -- Wisman, A -- Otto, S A -- de Roda Husman, A M -- Schaft, N -- de Wolf, F -- Goudsmit, J -- Coutinho, R A -- van der Zee, A G -- Meyaard, L -- Miedema, F -- New York, N.Y. -- Science. 1996 Nov 29;274(5292):1543-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Clinical Viro-Immunology, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam, The Netherlands. clbkvi@xs4all.nl〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8929418" target="_blank"〉PubMed〈/a〉
Keywords:
Acquired Immunodeficiency Syndrome/*blood
;
CD4 Lymphocyte Count
;
CD4-Positive T-Lymphocytes/enzymology/immunology/*pathology/ultrastructure
;
CD8-Positive T-Lymphocytes/enzymology/immunology/*pathology/ultrastructure
;
Cell Death
;
Cell Division
;
Cross-Sectional Studies
;
Disease Progression
;
HIV Infections/blood/*immunology
;
*Hiv-1
;
Humans
;
Leukocytes, Mononuclear/enzymology/pathology/ultrastructure
;
Lymphocyte Count
;
Male
;
Matched-Pair Analysis
;
Telomerase/blood
;
Telomere/*ultrastructure
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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