Publication Date:
2015-12-15
Description:
Individual variation in social behavior seems ubiquitous, but we know little about how it relates to brain diversity. Among monogamous prairie voles, levels of vasopressin receptor (encoded by the gene avpr1a) in brain regions related to spatial memory predict male space use and sexual fidelity in the field. We find that trade-offs between the benefits of male fidelity and infidelity are reflected in patterns of territorial intrusion, offspring paternity, avpr1a expression, and the evolutionary fitness of alternative avpr1a alleles. DNA variation at the avpr1a locus includes polymorphisms that reliably predict the epigenetic status and neural expression of avpr1a, and patterns of DNA diversity demonstrate that avpr1a regulatory variation has been favored by selection. In prairie voles, trade-offs in the fitness consequences of social behaviors seem to promote neuronal and molecular diversity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Okhovat, Mariam -- Berrio, Alejandro -- Wallace, Gerard -- Ophir, Alexander G -- Phelps, Steven M -- R21 HD059092/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 2015 Dec 11;350(6266):1371-4. doi: 10.1126/science.aac5791.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Integrative Biology, University of Texas at Austin, 1 University Station, Campus Code C0930, Austin, TX 78712, USA. ; Department of Psychology, Cornell University, 224 Uris Hall, Ithaca, NY 14853, USA. ; Department of Integrative Biology, University of Texas at Austin, 1 University Station, Campus Code C0930, Austin, TX 78712, USA. sphelps@mail.utexas.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26659055" target="_blank"〉PubMed〈/a〉
Keywords:
Alleles
;
Animals
;
Arvicolinae/genetics/metabolism/*psychology
;
Biological Evolution
;
Brain/*metabolism
;
DNA/genetics
;
Epigenesis, Genetic
;
Female
;
Grassland
;
Male
;
Polymorphism, Genetic
;
Receptors, Vasopressin/genetics/*metabolism
;
Sexual Behavior/*physiology
;
Sexual Behavior, Animal/*physiology
;
*Social Behavior
;
Spatial Memory/*physiology
;
Territoriality
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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