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  • 1
    Electronic Resource
    Electronic Resource
    Transplantation of Human Embryonic Oligodendrocytes into Shiverer Brain (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 495 (1987), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1987.tb23666.x
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Correspondentie (1872)
    Springer
    De economist 21 (1872), S. 591-596 
    Details
    ISSN: 1572-9982
    Source: Springer Online Journal Archives 1860-2000
    Topics: Economics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02180668
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Deutsche Geweih-Ausstellung (1897)
    Springer
    European journal of forest research 19 (1897), S. 64-64 
    Details
    ISSN: 1612-4677
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01842347
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    Paper (German National Licenses)
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  • 4
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    Global scaling of the heat transport in fusion plasmas (2020)
    American Physical Society
    Details
    Publication Date: 2020-01-08
    Electronic ISSN: 2643-1564
    Topics: Physics
    Published by American Physical Society
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  • 5
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    Structure of a Plasmodium falciparum PfEMP1 rosetting domain reveals a role for the N-terminal segment in heparin-mediated rosette inhibition [Biochemistry] (2011)
    National Academy of Sciences
    Details
    Publication Date: 2011-03-30
    Description: The human malaria parasite Plasmodium falciparum can cause infected red blood cells (iRBC) to form rosettes with uninfected RBC, a phenotype associated with severe malaria. Rosetting is mediated by a subset of the Plasmodium falciparum membrane protein 1 (PfEMP1) variant adhesins expressed on the infected host-cell surface. Heparin and other sulfated oligosaccharides, however, can disrupt rosettes, suggesting that therapeutic approaches to this form of severe malaria are feasible. We present a structural and functional study of the N-terminal domain of PfEMP1 from the VarO variant comprising the N-terminal segment (NTS) and the first DBL domain (DBL1α1), which is directly implicated in rosetting. We demonstrate that NTS-DBL1α1-VarO binds to RBC and that heparin inhibits this interaction in a dose-dependent manner, thus mimicking heparin-mediated rosette disruption. We have determined the crystal structure of NTS-DBL1α1, showing that NTS, previously thought to be a structurally independent component of PfEMP1, forms an integral part of the DBL1α domain. Using mutagenesis and docking studies, we have located the heparin-binding site, which includes NTS. NTS, unique to the DBL α-class domain, is thus an intrinsic structural and functional component of the N-terminal VarO domain. The specific interaction observed with heparin opens the way for developing antirosetting therapeutic strategies.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 6
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    Attenuation Coefficient of Single-Mode Periodic Waveguides (2011)
    American Physical Society (APS)
    Details
    Publication Date: 2011-10-06
    Description: Author(s): A. Baron, S. Mazoyer, W. Smigaj, and P. Lalanne [Phys. Rev. Lett. 107, 153901] Published Wed Oct 05, 2011
    Keywords: Nonlinear Dynamics, Fluid Dynamics, Classical Optics, etc.
    Print ISSN: 0031-9007
    Electronic ISSN: 1079-7114
    Topics: Physics
    Published by American Physical Society (APS)
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  • 7
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    Sec-independent protein translocation by the maize Hcf106 protein (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-12-31
    Description: The bacterial Sec and signal recognition particle (ffh-dependent) protein translocation mechanisms are conserved between prokaryotes and higher plant chloroplasts. A third translocation mechanism in chloroplasts [the proton concentration difference (DeltapH) pathway] was previously thought to be unique. The hcf106 mutation of maize disrupts the localization of proteins transported through this DeltapH pathway in isolated chloroplasts. The Hcf106 gene encodes a receptor-like thylakoid membrane protein, which shows homology to open reading frames from all completely sequenced bacterial genomes, which suggests that the DeltapH pathway has been conserved since the endosymbiotic origin of chloroplasts. Thus, the third protein translocation pathway, of which HCF106 is a component, is found in both bacteria and plants.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Settles, A M -- Yonetani, A -- Baron, A -- Bush, D R -- Cline, K -- Martienssen, R -- New York, N.Y. -- Science. 1997 Nov 21;278(5342):1467-70.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9367960" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Bacterial Proteins/chemistry/genetics ; Carrier Proteins/metabolism ; Chloroplast Proteins ; Chloroplasts/chemistry/*metabolism ; Evolution, Molecular ; Genes, Plant ; Hydrogen-Ion Concentration ; Intracellular Membranes/chemistry ; Membrane Proteins/*chemistry/genetics/*metabolism ; Methylamines/metabolism ; Molecular Sequence Data ; Mutation ; Open Reading Frames ; Plant Proteins/*metabolism ; Sequence Alignment ; Zea mays/genetics/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Black mamba venom peptides target acid-sensing ion channels to abolish pain (2012)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2012-10-05
    Description: Polypeptide toxins have played a central part in understanding physiological and physiopathological functions of ion channels. In the field of pain, they led to important advances in basic research and even to clinical applications. Acid-sensing ion channels (ASICs) are generally considered principal players in the pain pathway, including in humans. A snake toxin activating peripheral ASICs in nociceptive neurons has been recently shown to evoke pain. Here we show that a new class of three-finger peptides from another snake, the black mamba, is able to abolish pain through inhibition of ASICs expressed either in central or peripheral neurons. These peptides, which we call mambalgins, are not toxic in mice but show a potent analgesic effect upon central and peripheral injection that can be as strong as morphine. This effect is, however, resistant to naloxone, and mambalgins cause much less tolerance than morphine and no respiratory distress. Pharmacological inhibition by mambalgins combined with the use of knockdown and knockout animals indicates that blockade of heteromeric channels made of ASIC1a and ASIC2a subunits in central neurons and of ASIC1b-containing channels in nociceptors is involved in the analgesic effect of mambalgins. These findings identify new potential therapeutic targets for pain and introduce natural peptides that block them to produce a potent analgesia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Diochot, Sylvie -- Baron, Anne -- Salinas, Miguel -- Douguet, Dominique -- Scarzello, Sabine -- Dabert-Gay, Anne-Sophie -- Debayle, Delphine -- Friend, Valerie -- Alloui, Abdelkrim -- Lazdunski, Michel -- Lingueglia, Eric -- England -- Nature. 2012 Oct 25;490(7421):552-5. doi: 10.1038/nature11494. Epub 2012 Oct 3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉CNRS, Institut de Pharmacologie Moleculaire et Cellulaire, UMR 7275, 06560 Valbonne, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23034652" target="_blank"〉PubMed〈/a〉
    Keywords: Acid Sensing Ion Channel Blockers/chemistry/*pharmacology/therapeutic use ; Acid Sensing Ion Channels/classification/genetics/*metabolism ; Analgesics/adverse effects/chemistry/*pharmacology/therapeutic use ; Animals ; Drug Tolerance ; Elapid Venoms/administration & dosage/chemistry/*pharmacology/therapeutic use ; Injections, Spinal ; Male ; Mice ; Mice, Inbred C57BL ; Molecular Sequence Data ; Morphine/adverse effects/pharmacology ; Naloxone/pharmacology ; Nociceptors/chemistry/metabolism ; Oocytes/drug effects/metabolism ; Pain/*drug therapy/metabolism ; Peptides/administration & dosage/chemistry/*pharmacology/*therapeutic use ; Protein Subunits/antagonists & inhibitors/metabolism ; Rats ; Respiratory Insufficiency/chemically induced ; Xenopus laevis
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 9
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    Multiple optimality criteria support Ornithoscelida (2017)
    Royal Society
    Details
    Publication Date: 2017-10-26
    Description: A recent study of early dinosaur evolution using equal-weights parsimony recovered a scheme of dinosaur interrelationships and classification that differed from historical consensus in a single, but significant, respect; Ornithischia and Saurischia were not recovered as monophyletic sister-taxa, but rather Ornithischia and Theropoda formed a novel clade named Ornithoscelida. However, these analyses only used maximum parsimony, and numerous recent simulation studies have questioned the accuracy of parsimony under equal weights. Here, we provide additional support for this alternative hypothesis using Bayesian implementation of the Mkv model, as well as through number of additional parsimony analyses, including implied weighting. Using Bayesian inference and implied weighting, we recover the same fundamental topology for Dinosauria as the original study, with a monophyletic Ornithoscelida, demonstrating that the main suite of methods used in morphological phylogenetics recover this novel hypothesis. This result was further scrutinized through the systematic exclusion of different character sets. Novel characters from the original study (those not taken or adapted from previous phylogenetic studies) were found to be more important for resolving the relationships within Dinosauromorpha than the relationships within Dinosauria. Reanalysis of a modified version of the character matrix that supports the Ornithischia–Saurischia dichotomy under maximum parsimony also supports this hypothesis under implied weighting, but not under the Mkv model, with both Theropoda and Sauropodomorpha becoming paraphyletic with respect to Ornithischia.
    Keywords: palaeontology, evolution
    Electronic ISSN: 2054-5703
    Topics: Natural Sciences in General
    Published by Royal Society
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  • 10
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    Absolute pitch exhibits phenotypic and genetic overlap with synesthesia (2013)
    Oxford University Press
    Details
    Publication Date: 2013-04-24
    Description: Absolute pitch (AP) and synesthesia are two uncommon cognitive traits that reflect increased neuronal connectivity and have been anecdotally reported to occur together in an individual. Here we systematically evaluate the occurrence of synesthesia in a population of 768 subjects with documented AP. Out of these 768 subjects, 151 (20.1%) reported synesthesia, most commonly with color. These self-reports of synesthesia were validated in a subset of 21 study subjects, using an established methodology. We further carried out combined linkage analysis of 53 multiplex families with AP and 36 multiplex families with synesthesia. We observed a peak NPL LOD = 4.68 on chromosome 6q, as well as evidence of linkage on chromosome 2, using a dominant model. These data establish the close phenotypic and genetic relationship between AP and synesthesia. The chromosome 6 linkage region contains 73 genes; several leading candidate genes involved in neurodevelopment were investigated by exon resequencing. However, further studies will be required to definitively establish the identity of the causative gene(s) in the region.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
    Published by Oxford University Press
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