Publication Date:
1988-04-01
Description:
The neural cell adhesion molecule (NCAM) can influence a number of diverse intercellular events, including junctional communication, the association of axons with pathways and targets, and signals that alter levels of neurotransmitter enzymes. These pleiotropic effects appear to reflect the ability of NCAM to regulate membrane-membrane contact required to initiate specific interactions between other molecules. Such regulation can occur through changes in either NCAM expression or the molecule's content of polysialic acid (PSA). When NCAM with a low PSA content is expressed, adhesion is increased and contact-dependent events are triggered. In contrast, the large excluded volume of NCAM PSA can inhibit cell-cell interactions through hindrance of overall membrane apposition.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rutishauser, U -- Acheson, A -- Hall, A K -- Mann, D M -- Sunshine, J -- EY06107/EY/NEI NIH HHS/ -- HD18369/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1988 Apr 1;240(4848):53-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Developmental Genetics and Anatomy, Case Western Reserve University School of Medicine, Cleveland, OH 44106.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3281256" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigens, Surface/*physiology
;
Cell Adhesion
;
Cell Adhesion Molecules
;
*Cell Communication
;
Cell Membrane/physiology
;
Membrane Glycoproteins/physiology
;
Sialic Acids/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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