ISSN:
1573-0646
Keywords:
4-epi-doxorubicin
;
metastatic colorectal carcinoma
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary Twenty-three patients with metastatic colorectal carcinoma were treated with 4′-epi-doxorubicin (Epirubicin, 4′-epi-DX) 90 mg/m2 i.v. every 4 weeks. Out of 18 patients evaluable for response, 11 were previously untreated. One complete response of 21 + months was observed in a patient with rectosigmoid carcinoma. Furthermore there was one minor response in pretreated rectosigmoid series, and 6 patients had stabilization of disease. Median survival for all patients, including early deaths, was 4 months. For patients who were not pretreated and who received at least 2 cycles of therapy, median survival was 15 months. Further studies in patients with rectosigmoid carcinoma are warranted.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00171592
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