ISSN:
1042-7147
Keywords:
polycaprolactone-poly(ethylene glycol) block copolymer
;
blended polymer
;
XPS
;
surface property
;
drug release behavior
;
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
,
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
The surface properties of polycaprolactone (PCL)-poly(ethylene glycol) (PEG) block copolymer (PCE) and blend (B-PCE) of PCL and PEG obviously affect the drug release behavior of the polymer. In this paper, both surface properties of PCE and B-PCE are studied and compared by measuring their water sorption and using the contact angle and X-ray photoelectron spectroscopy technique. The effect of the polyether segment content in PCE and B-PCE on hydrophilicity is discussed. The results show that a hydrophilic polyether segment moves towards the surface and enriches on the surface for either PCE or B-PCE. The enrichment content of the polyether segment of PCE and the hydrophilicity of its surface are higher than that of B-PCE. A reason for the different drug release rates for PCE and B-PCE is suggested.
Additional Material:
5 Ill.
Type of Medium:
Electronic Resource
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