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  • 1
    Publication Date: 2011-08-03
    Description: Plasmodium yoelii is an excellent model for studying malaria pathogenesis that is often intractable to investigate using human parasites; however, genetic studies of the parasite have been hindered by lack of genome-wide linkage resources. Here, we performed 14 genetic crosses between three pairs of P. yoelii clones/subspecies, isolated 75 independent recombinant progeny from the crosses, and constructed a high-resolution linkage map for this parasite. Microsatellite genotypes from the progeny formed 14 linkage groups belonging to the 14 parasite chromosomes, allowing assignment of sequence contigs to chromosomes. Growth-related virulent phenotypes from 25 progeny of one of the crosses were significantly associated with a major locus on chromosome 13 and with two secondary loci on chromosomes 7 and 10. The chromosome 10 and 13 loci are both linked to day 5 parasitemia, and their effects on parasite growth rate are independent but additive. The locus on chromosome 7 is associated with day 10 parasitemia. The chromosome 13 locus spans ∼220 kb of DNA containing 51 predicted genes, including the P. yoelii erythrocyte binding ligand, in which a C741Y substitution in the R6 domain is implicated in the change of growth rate. Similarly, the chromosome 10 locus spans ∼234 kb with 71 candidate genes, containing a member of the 235-kDa rhoptry proteins (Py235) that can bind to the erythrocyte surface membrane. Atypical virulent phenotypes among the progeny were also observed. This study provides critical tools and information for genetic investigations of virulence and biology of P. yoelii.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 2
    Publication Date: 2014-05-21
    Description: Circulating cell-free RNA in the blood provides a potential window into the health, phenotype, and developmental programs of a variety of human organs. We used high-throughput methods of RNA analysis such as microarrays and next-generation sequencing to characterize the global landscape circulating RNA in a cohort of human subjects. By...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 3
    Publication Date: 2015-08-05
    Description: We have fabricated a superconductor (Ta)-InAs/GaSb bilayer-superconductor (Ta) junction device that has a long mean free path and can preserve the wavelike properties of particles (electrons and holes) inside the junction. Differential conductance measurements were carried out at low temperatures in this device, and McMillan-Rowell like oscillations (MROs) were observed. Surprisingly, a much larger Fermi velocity, compared to that from Shubnikov-de Haas oscillations, was obtained from the frequency of MROs. Possible mechanisms are discussed for this discrepancy.
    Print ISSN: 0003-6951
    Electronic ISSN: 1077-3118
    Topics: Physics
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  • 4
    Publication Date: 2016-07-01
    Description: We examine the late-time ( t 200 d after peak brightness) spectra of Type Iax supernovae (SNe Iax), a low-luminosity, low-energy class of thermonuclear stellar explosions observationally similar to, but distinct from, Type Ia supernovae. We present new spectra of SN 2014dt, resulting in the most complete late-time spectral sequence of an SN Iax. At late times, SNe Iax have generally similar spectra, all with a similar continuum shape and strong forbidden-line emission. However, there is also significant diversity where some SN Iax spectra display narrow P-Cygni features from permitted lines and a continuum indicative of a photosphere at late times in addition to strong narrow (FWHM 〈 3500 km s –1 ) forbidden lines, others have no obvious P-Cygni features, strong broad (FWHM 〉 6000 km s –1 ) forbidden lines, and weak narrow forbidden lines, and some SNe Iax have spectra intermediate to these two varieties. We find that SNe Iax with strong broad forbidden lines are more luminous and have higher velocity ejecta at peak brightness. We estimate blackbody and kinematic radii of the late-time photosphere, finding the latter significantly larger than the former. We propose a two-component model that solves this discrepancy and explains the diversity of the late-time spectra of SNe Iax. In this model, the broad forbidden lines originate from the SN ejecta, while the photosphere, P-Cygni lines, and narrow forbidden lines originate from a wind launched from the remnant of the progenitor white dwarf and is driven by the radioactive decay of newly synthesized material left in the remnant. The relative strength of the two components accounts for the diversity of late-time SN Iax spectra. This model also solves the puzzle of a long-lived photosphere and the slow late-time decline of SNe Iax.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
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  • 5
    Publication Date: 2015-12-19
    Description: In the development of a helium refrigerator, the control of load temperature stability is an important requirement. We usually use multistage control strategies to achieve the precise control of it. Each level has its strict control logic. PID controllers are the core control module in the process. Therefore, a research of its principle and parameters’ setting occupies an important position in the development work. This paper detailed describes the PID control principle used in a large scale helium refrigerator of 10kW@20K, as well as several improvements on PID parameters’ setting, by using simulations and experiments in combination. The temperature is eventually controlled more precise.
    Print ISSN: 1757-8981
    Electronic ISSN: 1757-899X
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
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  • 6
    Publication Date: 2015-01-22
    Description: Two-dimensional hole gases (2DHGs) have attracted recent attention for their unique quantum physics and potential applications in areas including spintronics and quantum computing. However, their properties remain relatively unexplored, motivating the use of different techniques to study them. We used terahertz magneto-optical spectroscopy to investigate the cyclotron resonance frequency in a high mobility 2DHG, revealing a nonlinear dependence on the applied magnetic field. This is shown to be due to the complex non-parabolic valence band structure of the 2DHG, as verified by multiband Landau level calculations. We also find that impurity scattering dominates cyclotron resonance decay in the 2DHG, in contrast with the dominance of superradiant damping in two-dimensional electron gases. Our results shed light on the properties of 2DHGs, motivating further studies of these unique 2D nanosystems.
    Print ISSN: 0003-6951
    Electronic ISSN: 1077-3118
    Topics: Physics
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  • 7
    Publication Date: 2015-01-10
    Description: Author(s): W. Pan, K. W. Baldwin, K. W. West, L. N. Pfeiffer, and D. C. Tsui We report low-temperature electronic transport results on the fractional quantum Hall effect of composite fermions at Landau level filling ν=4/11 in a very high mobility and low density sample. Measurements were carried out at temperatures down to 15 mK, where an activated magnetoresistance R xx and ... [Phys. Rev. B 91, 041301] Published Fri Jan 09, 2015
    Keywords: Semiconductors II: surfaces, interfaces, microstructures, and related topics
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
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  • 8
    Publication Date: 2015-06-12
    Description: Phase-field models have been developed to simulate the dendritic growth in pressurized solidification of Mg-Al alloy during squeeze casting and the precipitation of multivariant ?-Mg 17 Al 12 phases during the subsequent aging process. For the pressurized solidification, the effects of pressure on the Gibbs free energy and chemical potential of solid and liquid phases, and the solute diffusion coefficient were considered. For the precipitation during aging process, the effects of elastic strain energy, anisotropy of interfacial energy, and anisotropy of interface mobility coefficient were considered. The results showed that the dendritic growth rate tends to increase and the secondary dendrite arms are more developed as the pressure is increased from 0.1 to 100MPa, which showed a good agreement with the experimental results of direct squeeze casting of Mg-Al alloy. The 2D and 3D simulated precipitates had lath shapes with lozenge ends, and the precipitate varia...
    Print ISSN: 1757-8981
    Electronic ISSN: 1757-899X
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
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  • 9
    Publication Date: 2015-10-08
    Description: Superconductivity in topological materials has attracted a great deal of interest in both electron physics and material sciences since the theoretical predictions that Majorana fermions can be realized in topological superconductors. Topological superconductivity could be realized in a type II, band-inverted, InAs/GaSb quantum well if it is in proximity to a conventional superconductor. Here, we report observations of the proximity effect induced giant supercurrent states in an InAs/GaSb bilayer system that is sandwiched between two superconducting tantalum electrodes to form a superconductor-InAs/GaSb-superconductor junction. Electron transport results show that the supercurrent states can be preserved in a surprisingly large temperature-magnetic field ( T – H ) parameter space. In addition, the evolution of differential resistance in T and H reveals an interesting superconducting gap structure.
    Print ISSN: 0021-8979
    Electronic ISSN: 1089-7550
    Topics: Physics
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  • 10
    Publication Date: 2015-10-29
    Description: An Early Cretaceous highly enriched mantle beneath the Dabie Orogen, previously proposed on the basis of exceedingly enriched isotopic signatures documented in intermediate–mafic–ultramafic complexes, has been re-evaluated by new field, mineralogical and geochemical data from the best exposed Xiaohekou complex. The Xiaohekou complex consists of three pyroxenite cores intruded by olivine gabbronorite dykes and successively surrounded outward by gabbroic rocks, leucogabbros and monzonites. Textural and compositional data for pyroxenes and plagioclase as well as whole-rock geochemistry suggest two-stage crystallizations. The Sr–Nd isotopic values correlate with the SiO 2 and MgO contents, and one gabbronorite sample from the margin of the complex has sodic plagioclase and highly enriched Sr–Nd isotopic ratios, also pointing to fractional crystallizations and crustal contamination. One gabbro sample from the centre of the complex and three from olivine gabbronorite dykes have the lowest Sr but highest Nd isotopic values close to those of typical Enriched Mantle I (EMI). These data together with isotopic and MELTS modelling suggest that an EMI-like mantle source plus crustal assimilation and crystallization can explain all field, mineralogical and geochemical characteristics of the Xiaohekou complex, without the need to invoke a mantle source more enriched than EMI beneath the Dabie Orogen. Supplementary materials: Compositions of pyroxenes, feldspars, hornblende, olivine and biotite, and whole-rock major element oxides, trace element and Sr-Nd isotopic compositions from selected samples in the Xiaohekou complex are provided as .rtf files at http://www.geolsoc.org.uk/SUP18856 .
    Print ISSN: 0016-7649
    Topics: Geosciences
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