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  • 1
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    Acid-base balance and nitrogen excretion in invertebrates : mechanisms and strategies in various invertebrate groups with considerations of challenges caused by ocean acidification (2017)
    [Cham] : Springer
    Details
    Call number: 9783319396170 (e-book)
    Description / Table of Contents: This textbook provides a comprehensive overview on the diverse strategies invertebrate animals have developed for nitrogen excretion and maintenance of acid-base balance and summarizes the most recent findings in the field, obtained by state-of-the-art methodology. A broad range of terrestrial, freshwater and marine invertebrate groups are covered, including crustaceans, cephalopods, insects and worms. In addition the impact of current and future changes in ocean acidification on marine invertebrates due to anthropogenic CO2 release will be analyzed. The book addresses graduate students and young researchers interested in general animal physiology, comparative physiology and marine/aquatic animal physiology. Also it is an essential source for researchers dealing with the effects of increasing pCO2 levels on aquatic animals, of which the vast majority are indeed invertebrates. All chapters are peer-reviewed.
    Type of Medium: 12
    Pages: 1 Online-Ressource (x, 306 Seiten) , Illustrationen, Diagramme
    ISBN: 9783319396170 , 978-3-319-39617-0
    URL: Ebook (access only within the AWI network)
    DOI: 10.1007/978-3-319-39617-0
    Language: English
    Note: Contents 1 Nitrogen Excretion in Aquatic Crustaceans / Dirk Weihrauch, Sandra Fehsenfeld, and Alex Quijada-Rodriguez 2 Nitrogenous Waste Metabolism Within Terrestrial Crustacea, with Special Reference to Purine Deposits and Their Metabolism / Stuart M. Linton, Jonathan C. Wright, and Caitlin G. Howe 3 Gill Ion Transport ATPases and Ammonia Excretion in Aquatic Crustaceans / Francisco A. Leone, Malson N. Lucena, Daniela P. Garçon, Marcelo R. Pinto, and John C. McNamara 4 Nitrogen Excretion and Metabolism in Insects / M. J. O’Donnell and Andrew Donini 5 Nitrogen Excretion in Nematodes, Platyhelminthes, and Annelids / Alex R. Quijada-Rodriguez, Aida Adlimoghaddam, and Dirk Weihrauch 6 Acid–Base Regulation in Aquatic Decapod Crustaceans / Sandra Fehsenfeld and Dirk Weihrauch 7 Cell Biology of Reef-Building Corals: Ion Transport, Acid/Base Regulation, and Energy Metabolism / Martin Tresguerres, Katie L. Barott, Megan E. Barron, Dimitri D. Deheyn, David I. Kline, and Lauren B. Linsmayer 8 Acid–Base Regulation in Insect Haemolymph / Philip G.D. Matthews 9 Acid–Base Loops in Insect Larvae with Extremely Alkaline Midgut Regions / Horst Onken and David F. Moffett 10 pH Regulation and Excretion in Echinoderms / Meike Stumpp and Marian Y. Hu 11 Acid–Base Regulation and Ammonia Excretion in Cephalopods: An Ontogenetic Overview / Marian Hu and Yung-Che Tseng Service Part Index
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    E-BOOK
  • 2
    Electronic Resource
    Electronic Resource
    Proton nuclear magnetic resonance investigation of the mechanism of flavin C-4a adduct formation induced by oxidized nicotinamide adenine dinucleotide binding to monoalkylated pig heart lipoamide dehydrogenase (1983)
    s.l. : American Chemical Society
    Biochemistry 22 (1983), S. 3792-3796 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00285a012
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Reaction of both active site thiols of reduced thioredoxin reductase with N-ethylmaleimide (1985)
    s.l. : American Chemical Society
    Biochemistry 24 (1985), S. 7617-7621 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00347a018
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  • 4
    Electronic Resource
    Electronic Resource
    Exporting new public management: performance agreements in a Pacific microstate (2005)
    Bingley : Emerald
    International journal of public sector management 18 (2005), S. 615-628 
    Details
    ISSN: 0951-3558
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Political Science , Economics
    Notes: Purpose - The purpose of this article is to explore the export of new public management (NPM) to developing countries and to describe and evaluate the introduction of these initiatives in very different environments from their origins. Design/methodology/approach - The article traces the introduction of performance agreements into the public service of Vanuatu. Performance agreements are identified as an initiative typically promoted by NPM. The Vanuatu case is set within a review of the origin, use and record of performance agreements in countries such as Australia, the UK and the USA. Findings - The adoption of performance agreements has been slow and has enjoyed limited success. Among the difficulties encountered are suspicion, lack of incentives, an unreceptive environment, and possible identification as being donor-driven. It is difficult to see performance agreements in their current form making an impact on performance improvement in the Vanuatu public service. Practical implications - NPM initiatives must be carefully considered before being transferred to other countries. They may offer benefits but what has worked in one environment will often need considerable modification, certain preconditions and lengthy lead-in time to be effective in another environment. Originality/value - There are few case studies of attempts to transfer NPM-style reforms to developing countries and none on performance agreements, yet many countries in the Pacific and elsewhere are becoming interested in this mode of performance management. This case study helps to fill this gap through description and analysis of the Vanuatu experience and provides practical lessons for others considering policy transfer of NPM initiatives such as performance agreements.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/09513550510624077
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  • 5
    Electronic Resource
    Electronic Resource
    Regulation of ooplasmic sodium and potassium activities in developing locust eggs (1992)
    New York, NY [u.a.] : Wiley-Blackwell
    Archives of Insect Biochemistry and Physiology 20 (1992), S. 23-34 
    Details
    ISSN: 0739-4462
    Keywords: Locusta migratoria ; embryogenesis ; ooplasm ; ionoregulation ; Chemistry ; Food Science, Agricultural, Medicinal and Pharmaceutical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Ooplasmic activities of potassium and sodium were measured with ion sensitive microelectrodes before and during the period of maximal water uptake which occurs 3-5 days after oviposition for eggs incubated at 37°C. Potassium activity increased from 84 mM in eggs before fertilization at 118 mM in eggs 1 day after fertilization (d1). Sodium activity increased from 8 mM to 29 mM over the same period. These changes exceeded those predicted from the decrease in water content (8%) during the first day after oviposition. Between d1 and d3, potassium and sodium activities decreased to values predicted on the basis of the 88% increase in egg water content. Although water content increased an additional 46% between d3 and d5, ooplasmic sodium activity remained constant at 11 mM and potassium activity increased from 64 mM to 74 mM during this time. Declines in concentrations of sodium and potassium measured in whole eggs by atomic absorption spectrometry mirrored the increase in egg water content. The results suggest that regulation of ooplasmic sodium and potassium activities is accomplished by release of these ions from internal stores, possibly the york spheres. © 1992 Wiley-Liss, Inc.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/arch.940200104
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  • 6
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    Understanding, characterizing, and communicating responses to ocean acidification : challenges and uncertainties (2015)
    The Oceanography Society
    Details
    Publication Date: 2022-05-25
    Description: Author Posting. © The Oceanography Society, 2015. This article is posted here by permission of The Oceanography Society for personal use, not for redistribution. The definitive version was published in Oceanography 28, no. 2 (2015): 30-39, doi:10.5670/oceanog.2015.29.
    Description: Over the past decade, ocean acidification (OA) has emerged as a major concern in ocean science. The field of OA is based on certainties—uptake of carbon dioxide into the global ocean alters its carbon chemistry, and many marine organisms, especially calcifiers, are sensitive to this change. However, the field must accommodate uncertainties about the seriousness of these impacts as it synthesizes and draws conclusions from multiple disciplines. There is pressure from stakeholders to expeditiously inform society about the extent to which OA will impact marine ecosystems and the people who depend on them. Ultimately, decisions about actions related to OA require evaluating risks about the likelihood and magnitude of these impacts. As the scientific literature accumulates, some of the uncertainty related to single-species sensitivity to OA is diminishing. Difficulties remain in scaling laboratory results to species and ecosystem responses in nature, though modeling exercises provide useful insight. As recognition of OA grows, scientists’ ability to communicate the certainties and uncertainties of our knowledge on OA is crucial for interaction with decision makers. In this regard, there are a number of valuable practices that can be drawn from other fields, especially the global climate change community. A generally accepted set of best practices that scientists follow in their discussions of uncertainty would be helpful for the community engaged in ocean acidification.
    Description: NOAA Ocean Acidification Program and National Marine Fisheries Service (DSB, MP), NSF-supported Center for Climate and Energy Decision Making (SCD), and NASA Ocean Biology and Biogeochemistry Program (SS).
    Repository Name: Woods Hole Open Access Server
    Type: Article
    Format: application/pdf
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    PAPER (OA)
  • 7
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    Mathematical description of eukaryotic chromosome replication (2019)
    National Academy of Sciences
    Details
    Publication Date: 2019-02-19
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 8
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    Quality control mechanisms exclude incorrect polymerases from the eukaryotic replication fork (2017)
    National Academy of Sciences
    Details
    Publication Date: 2017-01-09
    Description: The eukaryotic genome is primarily replicated by two DNA polymerases, Pol ε and Pol δ, that function on the leading and lagging strands, respectively. Previous studies have established recruitment mechanisms whereby Cdc45-Mcm2-7-GINS (CMG) helicase binds Pol ε and tethers it to the leading strand, and PCNA (proliferating cell nuclear antigen) binds tightly to Pol δ and recruits it to the lagging strand. The current report identifies quality control mechanisms that exclude the improper polymerase from a particular strand. We find that the replication factor C (RFC) clamp loader specifically inhibits Pol ε on the lagging strand, and CMG protects Pol ε against RFC inhibition on the leading strand. Previous studies show that Pol δ is slow and distributive with CMG on the leading strand. However, Saccharomyces cerevisiae Pol δ–PCNA is a rapid and processive enzyme, suggesting that CMG may bind and alter Pol δ activity or position it on the lagging strand. Measurements of polymerase binding to CMG demonstrate Pol ε binds CMG with a Kd value of 12 nM, but Pol δ binding CMG is undetectable. Pol δ, like bacterial replicases, undergoes collision release upon completing replication, and we propose Pol δ–PCNA collides with the slower CMG, and in the absence of a stabilizing Pol δ–CMG interaction, the collision release process is triggered, ejecting Pol δ on the leading strand. Hence, by eviction of incorrect polymerases at the fork, the clamp machinery directs quality control on the lagging strand and CMG enforces quality control on the leading strand.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 9
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    Mutagenic cost of ribonucleotides in bacterial DNA (2017)
    National Academy of Sciences
    Details
    Publication Date: 2017-10-16
    Description: Replicative DNA polymerases misincorporate ribonucleoside triphosphates (rNTPs) into DNA approximately once every 2,000 base pairs synthesized. Ribonucleotide excision repair (RER) removes ribonucleoside monophosphates (rNMPs) from genomic DNA, replacing the error with the appropriate deoxyribonucleoside triphosphate (dNTP). Ribonucleotides represent a major threat to genome integrity with the potential to cause strand breaks. Furthermore, it has been shown in the bacteriumBacillus subtilisthat loss of RER increases spontaneous mutagenesis. Despite the high rNTP error rate and the effect on genome integrity, the mechanism underlying mutagenesis in RER-deficient bacterial cells remains unknown. We performed mutation accumulation lines and genome-wide mutational profiling ofB. subtilislacking RNase HII, the enzyme that incises at single rNMP residues initiating RER. We show that loss of RER inB. subtiliscauses strand- and sequence-context–dependent GC → AT transitions. Using purified proteins, we show that the replicative polymerase DnaE is mutagenic within the sequence context identified in RER-deficient cells. We also found that DnaE does not perform strand displacement synthesis. Given the use of nucleotide excision repair (NER) as a backup pathway for RER in RNase HII-deficient cells and the known mutagenic profile of DnaE, we propose that misincorporated ribonucleotides are removed by NER followed by error-prone resynthesis with DnaE.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 10
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    Single-molecule visualization of Saccharomyces cerevisiae leading-strand synthesis reveals dynamic interaction between MTC and the replisome (2017)
    National Academy of Sciences
    Details
    Publication Date: 2017-09-18
    Description: The replisome, the multiprotein system responsible for genome duplication, is a highly dynamic complex displaying a large number of different enzyme activities. Recently, the Saccharomyces cerevisiae minimal replication reaction has been successfully reconstituted in vitro. This provided an opportunity to uncover the enzymatic activities of many of the components in a eukaryotic system. Their dynamic behavior and interactions in the context of the replisome, however, remain unclear. We use a tethered-bead assay to provide real-time visualization of leading-strand synthesis by the S. cerevisiae replisome at the single-molecule level. The minimal reconstituted leading-strand replisome requires 24 proteins, forming the CMG helicase, the Pol ε DNA polymerase, the RFC clamp loader, the PCNA sliding clamp, and the RPA single-stranded DNA binding protein. We observe rates and product lengths similar to those obtained from ensemble biochemical experiments. At the single-molecule level, we probe the behavior of two components of the replication progression complex and characterize their interaction with active leading-strand replisomes. The Minichromosome maintenance protein 10 (Mcm10), an important player in CMG activation, increases the number of productive replication events in our assay. Furthermore, we show that the fork protection complex Mrc1–Tof1–Csm3 (MTC) enhances the rate of the leading-strand replisome threefold. The introduction of periods of fast replication by MTC leads to an average rate enhancement of a factor of 2, similar to observations in cellular studies. We observe that the MTC complex acts in a dynamic fashion with the moving replisome, leading to alternating phases of slow and fast replication.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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