ISSN:
1365-2761
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Biology
,
Medicine
Notes:
Abstract. Ultrastructural changes occurring in juvenile channel catfish, Ictalurus punctatus Ratinesque, hepatocytes were examined following exposure to carbon tetrachloride (CCl4). Juvenile catfish were intraperitoneally injected with a sublethal dose of undiluted CCl4and controls, used for comparisons, received physiological saline. The rough endoplasmic rcticulum (RER) was slightly dilated by 1 h and was significantly dilated by 4 and 24 h post-CCl4-exposure. At 4 h, the RER became degranulated, mitochondrial eristae indistinct with electron dense flocculant matrieal deposits, and nuclear membranes indented. Autophagic vacuoles were present in some hepatocytes. Within 48 h post-exposure, the hepatocytes were indistinguishable from control hepatocytes. CCl4 can induce reversible or irreversible cell damage which appears dose dependent.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1365-2761.1992.tb00646.x
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