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  • 1
    Electronic Resource
    Electronic Resource
    Transformation of teratocarcinoma stem cells and fibroblasts with various vectors containing the Eco.gpt gene as a selection marker
    Amsterdam : Elsevier
    Experimental Cell Research 151 (1984), S. 494-501 
    Details
    ISSN: 0014-4827
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0014-4827(84)90398-7
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The human HIP gene, overexpressed in primary liver cancer encodes for a C-type carbohydrate binding protein with lactose binding activity
    Amsterdam : Elsevier
    FEBS Letters 337 (1994), S. 114-118 
    Details
    ISSN: 0014-5793
    Keywords: Fusion protein ; HIP ; Lactose binding protein ; Lectin ; Primary liver cancer
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(94)80640-3
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  • 3
    Electronic Resource
    Electronic Resource
    Persistence of transcription of the human β-globin gene in hybrids between transfected F9 embryonal carcinoma and L cells
    Amsterdam : Elsevier
    Cell Differentiation 15 (1984), S. 215-219 
    Details
    ISSN: 0045-6039
    Keywords: cell hybrids ; globin ; teratocarcinoma ; transcripts
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0045-6039(84)90077-0
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  • 4
    Electronic Resource
    Electronic Resource
    Differential expression of two linked selection genes (HSVI-tk and Eco.gpt) in transformed teratocarcinoma and in L cells (1985)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 124 (1985), S. 37-42 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Upon transfection of (TK-)F9 teratocarcinoma stem-cells and (TK-)L fibroblasts with a plasmid carrying two selection genes, Eco.gpt and HSVI-tk, selection for gpt gene yielded ten times fewer colonies than selection for tk. Only the transformed clones selected for gpt had measurable xanthine guanine phosphoribosyltransferase (XGPRT) activity (Jami et al., 1983). Eco.gpt coding for XGPRT was under the control of simian virus 40 (SV40) early genes' regulating sequences (SV-gpt). In the present study, it was verified that the low efficiency of gpt selection in mouse cells was not due to the eucaryotic controlling sequences added to the bacterial gene. The transformed clones selected for tk that had no XGPRT activity possessed at least one uninterrupted copy of the composite SV-gpt gene and as many copies of the transforming plasmid as the cells selected for gpt expression. In a further test, the gpt gene was placed under the control of tk-regulating sequences and inserted with the tk gene in the same vector. Under these conditions, expression of XGPRT in the transformed clones selected for tk was improved, even though relative selection for gpt remained low.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041240107
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  • 5
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    Wave of horse deaths on famed racetrack poses puzzle (2019)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2019
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    The Burst-Like Behavior of Aseismic Slip on a Rough Fault: The Creeping Section of the Haiyuan Fault, China (2015)
    Seismological Society of America (SSA)
    Details
    Publication Date: 2015-01-30
    Description: Recent observations suggesting the influence of creep on earthquakes nucleation and arrest are strong incentives to investigate the physical mechanisms controlling how active faults slip. We focus here on deriving generic characteristics of shallow creep along the Haiyuan fault, a major strike-slip fault in China, by investigating the relationship between fault slip and geometry. We use optical images and time series of Synthetic Aperture Radar data to map the surface fault trace and the spatiotemporal distribution of surface slip along the creeping section of the Haiyuan fault. The fault trace roughness shows a power-law behavior similar to that of the aseismic slip distribution, with a 0.8 roughness exponent, typical of a self-affine regime. One possible interpretation is that fault geometry controls to some extent the distribution of aseismic slip, as it has been shown previously for coseismic slip along active faults. Creep is characterized by local fluctuations in rates that we define as creep bursts. The potency of creep bursts follows a power-law behavior similar to the Gutenberg–Richter earthquake distribution, whereas the distribution of bursts velocity is non-Gaussian, suggesting an avalanche-like behavior of these slip events. Such similarities with earthquakes and lab experiments lead us to interpret the rich dynamics of creep bursts observed along the Haiyuan fault as resulting from long-range elastic interactions within the heterogeneous Earth’s crust.
    Print ISSN: 0037-1106
    Electronic ISSN: 1943-3573
    Topics: Geosciences , Physics
    Published by Seismological Society of America (SSA)
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  • 7
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    Along-strike variations of the partitioning of convergence across the Haiyuan fault system detected by InSAR (2016)
    Oxford University Press
    Details
    Publication Date: 2016-03-03
    Description: Oblique convergence across Tibet leads to slip partitioning with the coexistence of strike-slip, normal and thrust motion on major fault systems. A key point is to understand and model how faults interact and accumulate strain at depth. Here, we extract ground deformation across the Haiyuan Fault restraining bend, at the northeastern boundary of the Tibetan plateau, from Envisat radar data spanning the 2001–2011 period. We show that the complexity of the surface displacement field can be explained by the partitioning of a uniform deep-seated convergence. Mountains and sand dunes in the study area make the radar data processing challenging and require the latest developments in processing procedures for Synthetic Aperture Radar interferometry. The processing strategy is based on a small baseline approach. Before unwrapping, we correct for atmospheric phase delays from global atmospheric models and digital elevation model errors. A series of filtering steps is applied to improve the signal-to-noise ratio across high ranges of the Tibetan plateau and the phase unwrapping capability across the fault, required for reliable estimate of fault movement. We then jointly invert our InSAR time-series together with published GPS displacements to test a proposed long-term slip-partitioning model between the Haiyuan and Gulang left-lateral Faults and the Qilian Shan thrusts. We explore the geometry of the fault system at depth and associated slip rates using a Bayesian approach and test the consistency of present-day geodetic surface displacements with a long-term tectonic model. We determine a uniform convergence rate of 10 [8.6–11.5] mm yr –1 with an N89 [81–97]°E across the whole fault system, with a variable partitioning west and east of a major extensional fault-jog (the Tianzhu pull-apart basin). Our 2-D model of two profiles perpendicular to the fault system gives a quantitative understanding of how crustal deformation is accommodated by the various branches of this thrust/strike-slip fault system and demonstrates how the geometry of the Haiyuan fault system controls the partitioning of the deep secular motion.
    Keywords: Geodynamics and Tectonics
    Print ISSN: 0956-540X
    Electronic ISSN: 1365-246X
    Topics: Geosciences
    Published by Oxford University Press on behalf of The Deutsche Geophysikalische Gesellschaft (DGG) and the Royal Astronomical Society (RAS).
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  • 8
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    Revealing the cluster of slow transients behind a large slow slip event (2018)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2018-05-31
    Description: Capable of reaching similar magnitudes to large megathrust earthquakes [ M w (moment magnitude) 〉 7], slow slip events play a major role in accommodating tectonic motion on plate boundaries through predominantly aseismic rupture. We demonstrate here that large slow slip events are a cluster of short-duration slow transients. Using a dense catalog of low-frequency earthquakes as a guide, we investigate the M w 7.5 slow slip event that occurred in 2006 along the subduction interface 40 km beneath Guerrero, Mexico. We show that while the long-period surface displacement, as recorded by Global Positioning System, suggests a 6-month duration, the motion in the direction of tectonic release only sporadically occurs over 55 days, and its surface signature is attenuated by rapid relocking of the plate interface. Our proposed description of slow slip as a cluster of slow transients forces us to re-evaluate our understanding of the physics and scaling of slow earthquakes.
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    Donkeys face worldwide existential threat (2019)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2019
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 10
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    Geodetic slip solutions for the Mw = 7.4 Champerico (Guatemala) earthquake of 2012 November 7 and its postseismic deformation (2015)
    Oxford University Press
    Details
    Publication Date: 2015-03-18
    Description: As the first large subduction thrust earthquake off the coast of western Guatemala in the past several decades, the 2012 November 7 M w  = 7.4 earthquake offers the first opportunity to study coseismic and postseismic behaviour along a segment of the Middle America trench where frictional coupling makes a transition from weak coupling off the coast of El Salvador to strong coupling in southern Mexico. We use measurements at 19 continuous GPS sites in Guatemala, El Salvador and Mexico to estimate the coseismic slip and postseismic deformation of the November 2012 Champerico (Guatemala) earthquake. An inversion of the coseismic offsets, which range up to ~47 mm at the surface near the epicentre, indicates that up to ~2 m of coseismic slip occurred on a ~30 30 km rupture area between ~10 and 30 km depth, which is near the global CMT centroid. The geodetic moment of 13 10 19 N m and corresponding magnitude of 7.4 both agree well with independent seismological estimates. Transient postseismic deformation that was recorded at 11 GPS sites is attributable to a combination of fault afterslip and viscoelastic flow in the lower crust and/or mantle. Modelling of the viscoelastic deformation suggests that it constituted no more than ~30 per cent of the short-term postseismic deformation. GPS observations that extend six months after the earthquake are well fit by a model in which most afterslip occurred at the same depth or directly downdip from the rupture zone and released energy equivalent to no more than ~20 per cent of the coseismic moment. An independent seismological slip solution that features more highly concentrated coseismic slip than our own fits the GPS offsets well if its slip centroid is translated ~50 km to the west to a position close to our slip centroid. The geodetic and seismologic slip solutions thus suggest bounds of 2–7 m for the peak slip along a region of the interface no larger than 30 30 km.
    Keywords: Seismology
    Print ISSN: 0956-540X
    Electronic ISSN: 1365-246X
    Topics: Geosciences
    Published by Oxford University Press on behalf of The Deutsche Geophysikalische Gesellschaft (DGG) and the Royal Astronomical Society (RAS).
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