ISSN:
1572-9001
Keywords:
Phenylhydrazones
;
X-ray Crystallography
;
Anticancer Agents
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The X-ray crystal structures of 4,4′-dihydroxybenzophenone-2,4-dinitrophenylhydrazone (I) and 2,2′-dihydroxybenzophenone-2,4-dinitrophenylhydrazone (II) have been determined in order to study the structural characteristics of these molecules that may contribute to their antiestrogenic and cytotoxic properties. These structures have been compared to other hydrazone derivatives as well as tamoxifen, an antiestrogen drug presently used clinically for the treatment of breast cancer. Crystal data: (I) C19H14N4O6 · C4H10O; MW=468.0; monoclinic,P21;a=8.601(2), b=15.502(8), c=16.851(4) Å,β=98.58(2)°;Z=8; finalR=0.036 for 1904 observed reflections. (II C19H14N4O6 · H2O; MW=410.0; monoclinic,P21/c;a=7.603(2),b=19.552(4),c=12.493(3) Å,β=92.11(1)°;Z=4; finalR=0.045 for 1171 observed reflections.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00676833
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