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  • 1
    Electronic Resource
    Electronic Resource
    The drift of a one-dimensional self-repellent random walk with bounded increments (1994)
    Springer
    Probability theory and related fields 100 (1994), S. 513-544 
    Details
    ISSN: 1432-2064
    Keywords: 60K35 ; 58E30 ; 60F10 ; 60J15
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Summary Consider a one-dimensional walk (S k ) k having steps of bounded size, and weight the probability of the path with some factor 1−α∈(0,1) for every single self-intersection up to timen. We prove thatS n /S S converges towards some deterministic number called the effective drift of the self-repellent walk. Furthermore, this drift is shown to tend to the basic drift as α tends to 0 and, as α tends to 1, to the self-avoiding walk's drift which is introduced in [10]. The main tool of the present paper is a representation of the sequence of the local times as a functional of a certain Markov process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01268992
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  • 2
    Electronic Resource
    Electronic Resource
    Relationship between the Microstructure and the Properties of Undoped and Pb-Doped Hg-1223 Superconductors (1997)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 132-136 (Apr. 1997), p. 1219-1222 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/44/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.132-136.1219.pdf
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  • 3
    Electronic Resource
    Electronic Resource
    Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators (1998)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 393 (1998), S. 790-793 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Peroxisome proliferator-activated receptors (PPARs) are key players in lipid and glucose metabolism and are implicated in metabolic disorders predisposing to atherosclerosis, such as dyslipidaemia and diabetes. Whereas PPARγ promotes lipid storage by regulating adipocyte differentiation, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/31701
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  • 4
    Electronic Resource
    Electronic Resource
    Helicobacter exploits integrin for type IV secretion and kinase activation (2007)
    [s.l.] : Nature Publishing Group
    Nature 449 (2007), S. 862-866 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Integrins are important mammalian receptors involved in normal cellular functions as well as pathogenesis of chronic inflammation and cancer. We propose that integrins are exploited by the gastric pathogen and type-1 carcinogen Helicobacter pylori for injection of the bacterial oncoprotein ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature06187
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  • 5
    Electronic Resource
    Electronic Resource
    The drift of a one-dimensional self-avoiding random walk (1993)
    Springer
    Probability theory and related fields 96 (1993), S. 521-543 
    Details
    ISSN: 1432-2064
    Keywords: 60K35 ; 58E30 ; 60F10 ; 60J15
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Summary We prove that a self-avoiding random walk on the integers with bounded increments grows linearly. We characterize its drift in terms of the Frobenius eigenvalue of a certain one parameter family of primitive matrices. As an important tool, we express the local times as a two-block functional of a certain Markov chain, which is of independent interest.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01200208
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  • 6
    Electronic Resource
    Electronic Resource
    Doped Tl-1223 Superconductors (1998)
    Springer
    Journal of superconductivity 11 (1998), S. 107-108 
    Details
    ISSN: 1572-9605
    Keywords: Tl-superconductors ; preparation ; critical currents ; texturing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
    Notes: Abstract Doped Tl-1223 superconductors of the composition TlaBibPbcBanSr2−nCa2Cu3Oy (a = 0.50 − 0.76, b = 0, 0.16 and 0.3, c = 0.5, 0.24 and 0, n = 0.15 − 0.4) were prepared from oxidic Ba-Sr-Ca-Cu precursor material. Upon calcination of the tartrate gels or the nitrates, the respective amounts of Tl2O3, PbO and Bi2O3 were added to the oxidic powders by milling. The samples were sintered in silver foil. The specimens consisted predominantely of the Tl-1223 phase with small amounts of Tl-1212 and secondary phases. Tc(0)-values ranged between 115 K and 119 K with transition widths around 1 K. Transport critical current densities up to 1.4 kA cm−2 at 77 K were measured for the assintered samples. Texturing was obtained by repressing and resintering of the superconducting material followed by annealing at 750°C for 50 h in flowing oxygen. The transport critical current densities could be improved up to 7 kA cm−2 by the thermomechanical treatment. Microstructural studies yielded information on the alignment of the superconducting grains, on secondary phases and the porosities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1022662703194
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  • 7
    Electronic Resource
    Electronic Resource
    Integration eines heuristisch-optimierenden Verfahrens zur Lösung eines eindimensionalen Verschnittproblems in einem EDV-gestützten Produktionsplanungs- und-Steuerungssystem (1980)
    Springer
    OR spectrum 1 (1980), S. 251-259 
    Details
    ISSN: 1436-6304
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Economics
    Description / Table of Contents: Summary This contribution describes the solution of an one-dimensional cutting problem in the context of a production control system. The solution of the cutting problem is demonstrated at the example of the production of central heating radiator units. The procedure is subdivided in an initial heuristic phase in order to concentrate the problem description. Afterwards an optimization phase is added to find the best solution of the reduced problem by using Linear Programming. Test results of field experiences are given. The last part of the contribution shows the integration of this solution in the global material and machine planning and control moduls. This is done by the determination of the interfaces of the batch oriented production control system and the process control of an NC saw machine.
    Notes: Zusammenfassung In diesem Beitrag wird am Beispiel der Produktion von Radiator-Heizungskörpern die Lösung des Zuschnittproblems der Vor- und Rücklaufrohre mit einem heuristisch-optimierenden Verfahren dargestellt. Die heuristische Vorschaltphase des Verfahrens ermöglicht bei geschickter Wahl der Kriterien eine Reduktion der Dimension des Verschnittproblems, ohne die Lösungsgüte unzulässig einzuschränken. Im Rahmen der reduzierten Problembeschreibung folgt anschließend die Optimierungsphase durch Anwendung der Linearen Programmierung. Es werden Testergebnisse im praktischen Einsatz des Verfahrens beschrieben. Weiterhin wird die Betrachtung der Integration des Verfahrens in ein globales EDV-gestütztes Produktionsplanungs- und -steuerungssystem behandelt, indem die Schnittstellen in der Material- und Terminbewirtschaftung zwischen dem stapelorientierten Planungskonzept und der Prozeßkontrolle einer NC-Sägeanlage definiert werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01719502
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  • 8
    Electronic Resource
    Electronic Resource
    From a peptide lead to an orally active peptidomimetic fibrinogen receptor antagonist (1998)
    Springer
    International journal of peptide research and therapeutics 5 (1998), S. 215-221 
    Details
    ISSN: 1573-3904
    Keywords: antithrombotic drug ; glycoprotein GP IIb/IIIa ; pharmacophore hypothesis ; RGDS recognition motif
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Antagonists of the platelet fibrinogen receptor (GP IIb/IIIa receptor) are expected to be a new promising class of antithrombotic agents. The binding of fibrinogen to the fibrinogen receptor depends on an Arg-Gly-Asp-Ser (RGDS) tetrapeptide recognition motif. Structural modifications of the RGDS lead have led to the discovery of a non-peptide RGD mimetic GP IIb/IIIa antagonist20 (S 1197). Compound20 inhibits dose-dependently and reversibly human platelet aggregation. Modeling studies based on structure-activity data revealed the following structural features of the drug as important for receptor binding: the amidino group, the carboxylate group, hydrophobic substitutions at the carboxyl-terminus and at the side chain carrying the positive charge, the carboxyl-terminal NH group of the β-amino acid as a hydrogen bond donor and one oxygen atom of the hydantoin as a hydrogen bond acceptor. The ethyl ester prodrug of20 (S 5740) is an orally active antithrombotic agent which has the potential to be used to treat and prevent thrombotic diseases in humans.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02443472
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  • 9
    Electronic Resource
    Electronic Resource
    From a peptide lead to an orally active peptidomimetic fibrinogen receptor antagonist (1998)
    Springer
    International journal of peptide research and therapeutics 5 (1998), S. 215-221 
    Details
    ISSN: 1573-3904
    Keywords: antithrombotic drug ; glycoprotein GP IIb/IIIa ; pharmacophore hypothesis ; RGDS recognition motif
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Antagonists of the platelet fibrinogen receptor (GP IIb/IIIa receptor) are expected to be a new promising class of antithrombotic agents. The binding of fibrinogen to the fibrinogen receptor depends on an Arg-Gly-Asp-Ser (RGDS) tetrapeptide recognition motif. Structural modifications of the RGDS lead have led to the discovery of a non-peptide RGD mimetic GP IIb/IIIa antagonist 20 (S 1197). Compound 20 inhibits dose-dependently and reversibly human platelet aggregation. Modeling studies based on structure–activity data revealed the following structural features of the drug as important for receptor binding: the amidino group, the carboxylate group, hydrophobic substitutions at the carboxyl-terminus and at the side chain carrying the positive charge, the carboxyl-terminal NH group of the β-amino acid as a hydrogen bond donor and one oxygen atom of the hydantoin as a hydrogen bond acceptor. The ethyl ester prodrug of 20 (S 5740) is an orally active antithrombotic agent which has the potential to be used to treat and prevent thrombotic diseases in humans.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008849013123
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  • 10
    Electronic Resource
    Electronic Resource
    Neue S-Schutzgruppen für Cystein (1968)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 101 (1968), S. 681-693 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Verschiedene S-tert.-Aralkyl-Derivate des Cysteins (4a-g, 2a, b, 3a, 11, 12) wurden hergestellt. Sie lassen sich in bekannter Weise in Esterhydrochloride, in N-Benzyloxycarbonyl-, N-tert.-Butyloxycarbonyl- und N-Phthalyl-Verbindungen und deren aktivierte Ester, z. B. 4-Nitro-phenylester, überführen. Aus diesen Verbindungen können nach bekannten Methoden Peptide erhalten werden. Die selektive Entfernung der N-Schutzgruppen mittels HCl/Eisessig, HBr/Eisessig oder Hydrazin ist möglich. Die neuen S-Schutzgruppen sind auch gegen Alkali und Amine stabil; ihre Abspaltung gelingt mit siedender Trifluoressigsäure auch ohne Zusatz eines Kationen bindenden Reagens wie Anisol.
    Additional Material: 4 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19681010239
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