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  • 1
    Publication Date: 2022-05-25
    Description: Author Posting. © American Geophysical Union, 2018. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research: Oceans 123 (2018): 4693-4719, doi:10.1029/2018JC013930.
    Description: We present a new methodology that is able to concurrently resolve free surface wavefield, bottom boundary layer, and sediment transport processes throughout the entire water column. The new model, called SedWaveFoam, is developed by integrating an Eulerian two‐phase model for sediment transport, SedFoam, and a surface wave solver, InterFoam/waves2Foam, in the OpenFOAM framework. SedWaveFoam is validated with a large wave flume data for sheet flow driven by monochromatic nonbreaking waves. To isolate the effect of free surface, SedWaveFoam results are contrasted with one‐dimensional‐vertical SedFoam results, where the latter represents the oscillating water tunnel condition. Results demonstrate that wave‐averaged total sediment fluxes in both models are onshore‐directed; however, this onshore transport is significantly enhanced under surface waves. Onshore‐directed near‐bed sediment flux is driven by a small mean current mainly associated with velocity skewness. More importantly, progressive wave streaming drives onshore transport mostly in suspended load region due to an intrawave sediment flux. Further analysis suggests that the enhanced onshore transport in suspended load is due to a “wave‐stirring” mechanism, which signifies a nonlinear interaction between waves, streaming currents, and sediment suspension. We present some preliminary efforts to parameterize the wave‐stirring mechanism in intrawave sediment transport formulations.
    Description: Office of Naval Research Grant Number: N00014‐16‐1‐2853; NSF Grant Numbers: OCE‐1635151, OCE‐1356855
    Description: 2019-01-05
    Keywords: Sediment transport ; Multiphase flow ; Surface waves ; Boundary layer streaming ; Sheet flow
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 2
    Publication Date: 2022-10-20
    Description: Author Posting. © American Geophysical Union, 2021. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research: Oceans 126(2), (2021): e2020JC016773, https://doi.org/10.1029/2020JC016773.
    Description: A new modeling methodology for ripple dynamics driven by oscillatory flows using a Eulerian two‐phase flow approach is presented in order to bridge the research gap between near‐bed sediment transport via ripple migration and suspended load transport dictated by ripple induced vortices. Reynolds‐averaged Eulerian two‐phase equations for fluid phase and sediment phase are solved in a two‐dimensional vertical domain with a k‐ε closure for flow turbulence and particle stresses closures for short‐lived collision and enduring contact. The model can resolve full profiles of sediment transport without making conventional near‐bed load and suspended load assumptions. The model is validated with an oscillating tunnel experiment of orbital ripple driven by a Stokes second‐order (onshore velocity skewed) oscillatory flow with a good agreement in the flow velocity and sediment concentration. Although the suspended sediment concentration far from the ripple in the dilute region was underpredicted by the present model, the model predicts an onshore ripple migration rate that is in very good agreement with the measured value. Another orbital ripple case driven by symmetric sinusoidal oscillatory flow is also conducted to contrast the effect of velocity skewness. The model is able to capture a net offshore‐directed suspended load transport flux due to the asymmetric primary vortex consistent with laboratory observation. More importantly, the model can resolve the asymmetry of onshore‐directed near‐bed sediment flux associated with more intense boundary layer flow speed‐up during onshore flow cycle and sediment avalanching near the lee ripple flank which force the onshore ripple migration.
    Description: This study is supported by National Science Foundation (Grant no. OCE‐1635151) and Strategic Environmental Research and Development Program (Grant no. MR20‐1478).
    Description: 2021-06-29
    Keywords: Orbital ripples ; Ripple migration ; Sediment transport ; Two‐phase model
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 3
    Publication Date: 2022-10-20
    Description: Author Posting. © American Geophysical Union, 2020. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research-Oceans 125(2), (2020): e2019JC015220, doi:10.1029/2019JC015220.
    Description: Wave‐supported gravity flows (WSGFs) have been identified as a key process driving the offshore delivery of fine sediment across continental shelves. However, our understanding on the various factors controlling the maximum sediment load and the resulting gravity current speed remains incomplete. We adopt a new turbulence‐resolving numerical model for fine sediment transport to investigate the formation, evolution, and termination of WSGFs. We consider the simplest scenario in which fine sediments are supported by the wave‐induced fluid turbulence at a low critical shear stress of erosion over a flat sloping bed. Under the energetic wave condition reported on the Northern California Coast with a shelf slope of 0.005, simulation results show that WSGFs are transitionally turbulent and that the sediment concentration cannot exceed 30 kg/m urn:x-wiley:jgrc:media:jgrc23843:jgrc23843-math-0001 (g/L) due to the attenuation of turbulence by the sediment‐induced stable density stratification. Wave direction is found to be important in the resulting gravity current intensity. When waves are in cross‐shelf direction, the downslope current has a maximum velocity of 1.2 cm/s, which increases to 2.1 cm/s when waves propagate in the along‐shelf direction. Further analysis on the wave‐averaged momentum balance confirms that when waves are parallel to the slope (cross‐shelf) direction, the more intense wave‐current interaction results in larger wave‐averaged Reynolds shear stress and thus in a smaller current speed. Findings from this study suggest that the more intense cross‐shelf gravity current observed in the field may be caused by additional processes, which may enhance the sediment‐carrying capacity of flow, such as the ambient current or bedforms.
    Description: This study is supported by NSF (OCE‐1537231 and OCE‐1924532) and Office of Naval Research (N00014‐17‐1‐2796). Numerical simulations presented in this study were carried out using the Mills and Canviness clusters at University of Delaware, and the SuperMIC cluster at Louisiana State University via XSEDE (TG‐OCE100015). Z. Cheng would like to express thanks for the support of a postdoctoral scholarship from Woods Hole Oceanographic Institution. The source code and the case setup to reproduce the same results are publicly available via the repository maintained by GitHub: https://github.com/yueliangyi/TURBID (source code) and https://github.com/yueliangyi/TURBID/tree/master/spike/wave_supported_gravity_flow (case setup), respectively.
    Description: 2020-08-04
    Keywords: Wave‐supported gravity flows ; Turbulence‐resolving numerical simulation ; Wave direction ; Intermittently turbulent flow
    Repository Name: Woods Hole Open Access Server
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  • 4
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    Copernicus Publications on behalf of the European Geosciences Union
    Publication Date: 2022-05-26
    Description: © The Author(s), 2017. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Geoscientific Model Development 10 (2017): 4367–4392, doi:10.5194/gmd-10-4367-2017.
    Description: In this paper, a three-dimensional two-phase flow solver, SedFoam-2.0, is presented for sediment transport applications. The solver is extended from twoPhaseEulerFoam available in the 2.1.0 release of the open-source CFD (computational fluid dynamics) toolbox OpenFOAM. In this approach the sediment phase is modeled as a continuum, and constitutive laws have to be prescribed for the sediment stresses. In the proposed solver, two different intergranular stress models are implemented: the kinetic theory of granular flows and the dense granular flow rheology μ(I). For the fluid stress, laminar or turbulent flow regimes can be simulated and three different turbulence models are available for sediment transport: a simple mixing length model (one-dimensional configuration only), a k − ε, and a k − ω model. The numerical implementation is demonstrated on four test cases: sedimentation of suspended particles, laminar bed load, sheet flow, and scour at an apron. These test cases illustrate the capabilities of SedFoam-2.0 to deal with complex turbulent sediment transport problems with different combinations of intergranular stress and turbulence models.
    Description: Julien Chauchat, Tim Nagel, and Cyrille Bonamy are supported by the Region Rhones-Alpes (COOPERA project and Explora Pro grant), the French national programme EC2CO-LEFE MODSED. Zhen Cheng and Tian-Jian Hsu are supported by National Science Foundation (OCE-1537231; OCE-1635151) and Office of Naval Research (N00014-16-1-2853) of USA.
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 5
    Publication Date: 2022-05-26
    Description: Author Posting. © The Author(s), 2017. This is the author's version of the work. It is posted here under a nonexclusive, irrevocable, paid-up, worldwide license granted to WHOI. It is made available for personal use, not for redistribution. The definitive version was published in Advances in Water Resources 111 (2018): 435-451, doi:10.1016/j.advwatres.2017.11.019.
    Description: A Reynolds-averaged Euler–Lagrange sediment transport model (CFDEM-EIM) was developed for steady sheet flow, where the inter-granular interactions were resolved and the flow turbulence was modeled with a low Reynolds number corrected turbulence closure modified for two-phase flows. To model the effect of turbulence on the sediment suspension, the interaction between the turbulent eddies and particles was simulated with an eddy interaction model (EIM). The EIM was first calibrated with measurements from dilute suspension experiments. We demonstrated that the eddy-interaction model was able to reproduce the well-known Rouse profile for suspended sediment concentration. The model results were found to be sensitive to the choice of the coefficient, C0, associated with the turbulence-sediment interaction time. A value was suggested to match the measured concentration in the dilute suspension. The calibrated CFDEM-EIM was used to model a steady sheet flow experiment of lightweight coarse particles and yielded reasonable agreements with measured velocity, concentration and turbulence kinetic energy profiles. Further numerical experiments for sheet flow suggested that when C0 was decreased to C0 〈 3, the simulation under-predicted the amount of suspended sediment in the dilute region and the Schmidt number is over-predicted (Sc 〉 1.0). Additional simulations for a range of Shields parameters between 0.3 and 1.2 confirmed that CFDEM-EIM was capable of predicting sediment transport rates similar to empirical formulations. Based on the analysis of sediment transport rate and transport layer thickness, the EIM and the resulting suspended load were shown to be important when the fall parameter is less than 1.25.
    Description: Z. Cheng and T.-J. Hsu were supported by the U.S. Office of Naval Research (N00014- 16-1-2853) and National Science Foundation (OCE- 1537231). J. Chauchat was supported by the Région Rhones-Alpes (COOPERA project and Explora Pro grant) and the French national programme EC2CO-LEFE MODSED. J. Calantoni was supported under base funding to the U.S. Naval Research Laboratory from the U.S. Office of Naval Research. The authors would also like to acknowledge the support from the program on "Fluid- Mediated Particle Transport in Geophysical Flows" at the Kavli Institute for Theoretical Physics, Santa Barbara, USA.
    Keywords: Euler-Lagrange model ; Eddy interaction model ; Turbulent suspension ; Steady sheet flow ; Rouse profile ; Sediment transport rate
    Repository Name: Woods Hole Open Access Server
    Type: Preprint
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  • 6
    Publication Date: 2022-05-26
    Description: Author Posting. © The Author(s), 2017. This is the author's version of the work. It is posted here under a nonexclusive, irrevocable, paid-up, worldwide license granted to WHOI. It is made available for personal use, not for redistribution. The definitive version was published in Advances in Water Resources 111 (2018): 205-223, doi:10.1016/j.advwatres.2017.11.016.
    Description: A three-dimensional Eulerian two-phase flow model for sediment transport in sheet flow conditions is presented. To resolve turbulence and turbulence-sediment interactions, the large-eddy simulation approach is adopted. Specifically, a dynamic Smagorinsky closure is used for the subgrid fluid and sediment stresses, while the subgrid contribution to the drag force is included using a drift velocity model with a similar dynamic procedure. The contribution of sediment stresses due to intergranular interactions is modeled by the kinetic theory of granular flow at low to intermediate sediment concentration, while at high sediment concentration of enduring contact, a phenomenological closure for particle pressure and frictional viscosity is used. The model is validated with a comprehensive high-resolution dataset of unidirectional steady sheet flow (Revil-Baudard et al., 2015, Journal of Fluid Mechanics, 767, 1–30). At a particle Stokes number of about 10, simulation results indicate a reduced von Kármán coefficient of κ ≈ 0.215 obtained from the fluid velocity profile. A fluid turbulence kinetic energy budget analysis further indicates that the drag-induced turbulence dissipation rate is significant in the sheet flow layer, while in the dilute transport layer, the pressure work plays a similar role as the buoyancy dissipation, which is typically used in the single-phase stratified flow formulation. The present model also reproduces the sheet layer thickness and mobile bed roughness similar to measured data. However, the resulting mobile bed roughness is more than two times larger than that predicted by the empirical formulae. Further analysis suggests that through intermittent turbulent motions near the bed, the resolved sediment Reynolds stress plays a major role in the enhancement of mobile bed roughness. Our analysis on near-bed intermittency also suggests that the turbulent ejection motions are highly correlated with the upward sediment suspension flux, while the turbulent sweep events are mostly associated with the downward sediment deposition flux.
    Description: This study was supported by National Science Foundation (OCE-1635151; OCE- 958 1537231) and Office of Naval Research (N00014-16-1-2853). J. Chauchat was supported by the Region Rhones-Alpes (COOPERA project and Explora Pro grant) and the French national programme EC2CO-LEFE MODSED. The authors would also like to acknowledge the support from the program on "Fluid-Mediated Particle Transport in Geophysical Flows" at the Kavli Institute for Theoretical Physics, Santa Barbara, USA.
    Keywords: Large eddy simulation ; Sediment transport ; Sheet flow ; Two-phase flow ; Near-bed intermittency
    Repository Name: Woods Hole Open Access Server
    Type: Preprint
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  • 7
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 43 (1997), S. 1319-1324 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The Ergun equation based on the effective spherical diameter is universally valid for various shapes of granular packings. It, however, was derived from the assumption of infinite tube-to-particle diameter ratio without considering the wall effect. Although some improvements were made by Mehta and Hawley (1969) to correct this, the application of the Ergun equation is still restricted to cylindrical columns with a packing porosity of less than 0.5. To modify the Ergun equation to noncylindrical flow space with or without a wall, it was substituted into the empty tube pressure drop equation by introducing an effective tube diameter so that the pressure drop can be predicted just from the free flow space and the wetted area involved. This treatment offers the basis for a new method in velocity distribution prediction.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
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  • 8
    Publication Date: 2020-03-03
    Electronic ISSN: 2643-1564
    Topics: Physics
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  • 9
    Publication Date: 2018-02-12
    Description: Pituitary hormones have long been thought solely to regulate single targets. Challenging this paradigm, we discovered that both anterior and posterior pituitary hormones, including FSH, had other functions in physiology. We have shown that FSH regulates skeletal integrity, and, more recently, find that FSH inhibition reduces body fat and induces thermogenic adipose tissue. A polyclonal antibody raised against a short, receptor-binding epitope of FSHβ was found not only to rescue bone loss postovariectomy, but also to display marked antiobesity and probeiging actions. Questioning whether a single agent could be used to treat two medical conditions of public health importance––osteoporosis and obesity––we developed two further monoclonal antibodies, Hf2 and Mf4, against computationally defined receptor-binding epitopes of FSHβ. Hf2 has already been shown to reduce body weight and fat mass and cause beiging in mice on a high-fat diet. Here, we show that Hf2, which binds mouse Fsh in immunoprecipitation assays, also increases cortical thickness and trabecular bone volume, and microstructural parameters, in sham-operated and ovariectomized mice, noted on microcomputed tomography. This effect was largely recapitulated with Mf4, which inhibited bone resorption by osteoclasts and stimulated new bone formation by osteoblasts. These effects were exerted in the absence of alterations in serum estrogen in wild-type mice. We also reconfirm the existence of Fshrs in bone by documenting the specific binding of fluorescently labeled FSH, FSH-CH, in vivo. Our study provides the framework for the future development of an FSH-based therapeutic that could potentially target both bone and fat.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 10
    Publication Date: 2020-08-01
    Description: Mounting evidence suggests that immunotherapies are a promising new class of anticancer therapies. However, the immunosuppressive tumor microenvironment (TME), poor immunogenicity, and off-target toxicity hinder the broader implementation of immunotherapies. Here, we describe a novel strategy combining chemotherapy and immunotherapy to modulate the TME by systemically and concurrently delivering the chemotherapeutic agent SN38 (7-ethyl-10-hydroxycamptothecin) and the STING agonist DMXAA (5,6-dimethylxanthenone-4-acetic acid) into tumors using triblock copolymer nanoparticles, named PS3D1@DMXAA, which enhances antigen cross-presentation and induces the conversion of the immunosuppressive TME to immunogenic TME through the newly found synergistic function between SN38 and STING activation. PS3D1@DMXAA thus shows potent therapeutic efficacy in three mice tumor models and elicits remarkable therapeutic benefit when combined with anti–PD-1 therapy. Our engineered nanosystem offers a rational design of an effective immunotherapy combination regimen to convert uninflamed “cold” tumors into “hot” tumors, addressing the major challenges immunotherapies faced.
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
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