Publication Date:
2016-07-27
Description:
Article Tumour hypoxia reduces the efficacy of radiotherapy. Starting from a drug screen, here the authors demonstrate that the anti-malarial, atovaquone, reduces the oxygen consumption rate of cancer cells by inhibition of mitochondrial complex III and sensitises to radiotherapy by reducing tumour hypoxia. Nature Communications doi: 10.1038/ncomms12308 Authors: Thomas M. Ashton, Emmanouil Fokas, Leoni A. Kunz-Schughart, Lisa K. Folkes, Selvakumar Anbalagan, Melanie Huether, Catherine J. Kelly, Giacomo Pirovano, Francesca M. Buffa, Ester M. Hammond, Michael Stratford, Ruth J. Muschel, Geoff S. Higgins, William Gillies McKenna
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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