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  • 1
    ISSN: 1432-0827
    Keywords: Key words: Bone alkaline phosphatase — Biochemical markers — Bone turnover — Ovariectomy — Paget's disease of bone.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. The purpose of this study was to examine the serum levels of bone alkaline phosphatase (BALP) measured with a new assay in normal and in osteoporotic women, and to evaluate prospectively its responsiveness to changes of bone metabolism. The following groups of subjects were studied: (1) 95 healthy women (44–75 years) (22 pre- and 73 postmenopausal) and 35 osteoporotic women [vertebral bone mineral density (BMD) more than 2.5 SD below the normal adult mean]; (2) 10 women (44–50 years) ovariectomized (OVX) for benign uterine diseases, examined before and 12 months after surgery; (3) 16 OVX women (36–54 years), examined before and after 12 months of transdermal estrogen replacement therapy (50 μg/day); (4) 12 previously untreated pagetic patients (4 women and 8 men, 50–80 years), examined before and 3 months after the I.V. administration of clodronate (600 mg) or alendronate (5 mg) for 2 consecutive days. The median BALP value was 11.6 U/liter (25–75th percentiles: 10.5–12.7; range 7.7–19.3) in healthy premenopausal (PreMP) women and significantly higher (median: 16.8 U/liter; 25–75th percentile: 13.8–21.8; P 〈 0.01) in postmenopausal (PostMP) women. There was a clear age-related increase in normal subjects (r = 0.43; P 〈 0.001). In the osteoporotic group, BALP levels, as well as other biochemical parameters of bone turnover, were not significantly different from those of normal women when adjusted for age. In OVX women, BALP levels showed a marked increase 12 months after surgery (median: 113%; 25–75th percentile: 87–139%), significantly higher than the increase of total ALP (median: 43%; 25–75th percentile: 25–66%; P 〈 0.001), and similar to the increases of serum osteocalcin and urinary hydroxyproline. Transdermal estrogen treatment prevented the BALP increase, even if no reduction was observed; total ALP showed a similar behavior. The basal levels of BALP were significantly elevated in pagetic patients (median: 91 U/liter; range 18–610 U/liter) and correlated to the scintigraphic extent of the disease (r = 0.76; P 〈 0.01). Three months after the I.V. administration of bisphosphonates, the decrease of BALP was more marked than that of total ALP (median: −54% versus −41%; P 〈 0.05). In conclusion, these results suggest that BALP measurement with this immunoassay may be clinically useful, and more sensitive than total ALP, in the assessment of bone turnover during changes of the estrogen status as well as in monitoring the effects of treatments that modify the metabolic activity of the skeleton.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0827
    Keywords: Bisphosphonates ; Bone resorption ; Biochemical markers ; TRAP ; ICTP ; Hydroxyproline ; Pyridinium cross-links ; NTx
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract Bisphosphonates are known to be potent inhibitors of osteoclast activity and their only clinically relevant effect in the short-term is the selective inhibition of bone resorption. The purpose of this study was to compare the response to the intravenous administration of two bisphosphonates, clodronate and alendronate, of several biochemical markers of bone resorption, including tartrate-resistant acid phosphatase (TRAP) and cross-linked carboxyterminal telopeptide of collagen I (ICTP) in serum and hydroxyproline (OHP), free pyridinium cross-links (Pyr), and crosslinked N-telopeptides of collagen I (NTx) in urine. The study was carried out on 11 osteoporotic and 12 Pagetic subjects of both sexes, treated with clodronate (600 mg/day for 2 days) or alendronate (5 mg/day for 2 days), and monitored for 28 days after bisphosphonate administration. All the urinary markers of bone resorption showed a prompt decline after bisphosphonates, with maximum reductions after 7–14 days: Pyr decreased by 43%±9% and 42%±22% (mean ± SD), respectively in osteoporotic and pagetic subjects, OHP by 51%±14% and 51%±20%, and NTx by 55%±15% and 65%±26%. In the osteoporotic group, the urinary markers began to increase again at 30 days, though still remaining well below the basal level, whereas in the pagetic group, the excretion of all markers remained depressed until the end of the observation period. The reduction of NTx was significantly greater than that of Pyr and OHP in pagetic patients (P〈0.05) and tended to be greater than that of Pyr in osteoporotic patients (p=0.07). Serum levels of TRAP decreased slightly, with a maximum reduction after 7 days of 16%±22% and 21%±11% in osteoporotic and pagetic subjects, respectively. Serum ICTP levels showed a slow and limited decrease, with minimal values after 14 days in pagetic subjects (-9%±21%; p=NS) and 30 days in osteoporotic patients (13%±4%; P〈0.05). The cumulative changes of all urinary markers, expressed as area under the curve, were significantly greater than those observed for serum markers (P〈0.01). In conclusion, these results indicate that the new markers of bone resorption differ in their capacity to reflect the acute inhibition of bone resorption following the I.V. administration of bisphosphonates. The use of bisphosphonates may be a useful means to test new markers of bone resorption.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1615-6102
    Keywords: Abscission ; Actin filaments ; Cytokinesis ; Immunocytochemistry ; Microtubules ; Moss protonema ; Preprophase band
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary When grown on nutrient agar, protonemata ofBryum tenuisetum produce aerial filaments containing several abscission or tmema cells (TC). Basipetal migration of the nucleus and some of the chloroplasts signals the onset of TC formation. This is followed by the creation of a plastid-free zone at the base of the mother cell. The ensuing cytokinesis produces a very short aplastidic TC. This expands without the deposition of new wall material. Eventually the wall ruptures around the equator thus disrupting the protonemal filament. The site of wall breakdown is marked by a narrow band of cortical cytoplasm containing colocalized circumferential rings of actin filaments and microtubules. A transverse band of microtubules appears at the extreme basal end of the tmema mother cell. This band, which is not colocalized with actin filaments, migrates distally over the surface of the nucleus. Intimate spatial and developmental correlations suggest that this transverse array of the microtubules has a key role in excluding plastids from the TC. It is therefore considered not to be homologous with a preprophase band.
    Type of Medium: Electronic Resource
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  • 4
    Publication Date: 2018
    Description: 〈span〉Sunset Crater volcano, located ∼25 km northeast of downtown Flagstaff (Arizona, USA) in the San Francisco volcanic field, represents an interesting case of highly explosive monogenetic volcanism. Sunset Crater is a young (ca. 1085 CE) scoria cone, ∼290 m high, that produced 0.52 km〈sup〉3〈/sup〉 dense rock equivalent (DRE) of basaltic magma (0.16, 0.12, and 0.24 km〈sup〉3〈/sup〉 DRE for the scoria cone, lava flows, and tephra deposit, respectively). The activity developed in three distinct phases: an initial fissure phase, followed by a highly explosive phase, and a final low-explosivity waning phase. The first phase was characterized by the opening of a 10-km-long fissure, which produced the Gyp Crater spatter mounds and the Vent 512 lava flow ∼10 km SE of the main scoria cone, followed by lava fountaining activity that produced the first tephra layer (unit 1, 0.01 km〈sup〉3〈/sup〉 DRE). During the second highly explosive phase, the activity migrated to the northwest to evolve into a single-vent eruption, which formed the main scoria cone. The central vent activity was initially characterized by variable eruptive styles, which started the process of cone building, including deposition of a second tephra layer (unit 2, 0.01 km〈sup〉3〈/sup〉 DRE), and the effusion of the two main lava flows (Bonito and Kana’a). Following the initiation of effusive activity, the eruption increased in explosivity to produce three subplinian tephra layers from the central vent (units 3, 4, and 5), which emitted more than 0.22 km〈sup〉3〈/sup〉 DRE of basalt, with associated eruption columns 〉20 km high. By the end of this phase, the Kana’a lava flow was almost completely emplaced, but the Bonito flow continued to grow, forming a 3-km-diameter flow field. A final waning phase produced several tephra units, commonly discontinuous and reworked, with 〈0.01 km〈sup〉3〈/sup〉 DRE cumulative volume. The comparatively large volume of tephra, the high eruptive columns, and high mass eruption rates make Sunset Crater the most explosive monogenetic eruption studied to date (volcano explosivity index [VEI] 3−4). Sunset Crater volcano represents an interesting case of monogenetic volcanism in that its activity was characterized by highly explosive eruptive phases up to subplinian in scale and intermittent episodes of lava effusion that heavily affected prehistoric communities in the area. Explosive basaltic volcanism should be considered when assessing volcanic hazards in continental settings, such as in the western United States.〈/span〉
    Print ISSN: 0016-7606
    Electronic ISSN: 1943-2674
    Topics: Geosciences
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  • 5
    Publication Date: 2018
    Description: 〈span〉〈div〉Abstract〈/div〉Sunset Crater volcano, located ∼25 km northeast of downtown Flagstaff (Arizona, USA) in the San Francisco volcanic field, represents an interesting case of highly explosive monogenetic volcanism. Sunset Crater is a young (ca. 1085 CE) scoria cone, ∼290 m high, that produced 0.52 km〈sup〉3〈/sup〉 dense rock equivalent (DRE) of basaltic magma (0.16, 0.12, and 0.24 km〈sup〉3〈/sup〉 DRE for the scoria cone, lava flows, and tephra deposit, respectively). The activity developed in three distinct phases: an initial fissure phase, followed by a highly explosive phase, and a final low-explosivity waning phase. The first phase was characterized by the opening of a 10-km-long fissure, which produced the Gyp Crater spatter mounds and the Vent 512 lava flow ∼10 km SE of the main scoria cone, followed by lava fountaining activity that produced the first tephra layer (unit 1, 0.01 km〈sup〉3〈/sup〉 DRE). During the second highly explosive phase, the activity migrated to the northwest to evolve into a single-vent eruption, which formed the main scoria cone. The central vent activity was initially characterized by variable eruptive styles, which started the process of cone building, including deposition of a second tephra layer (unit 2, 0.01 km〈sup〉3〈/sup〉 DRE), and the effusion of the two main lava flows (Bonito and Kana’a). Following the initiation of effusive activity, the eruption increased in explosivity to produce three subplinian tephra layers from the central vent (units 3, 4, and 5), which emitted more than 0.22 km〈sup〉3〈/sup〉 DRE of basalt, with associated eruption columns 〉20 km high. By the end of this phase, the Kana’a lava flow was almost completely emplaced, but the Bonito flow continued to grow, forming a 3-km-diameter flow field. A final waning phase produced several tephra units, commonly discontinuous and reworked, with 〈0.01 km〈sup〉3〈/sup〉 DRE cumulative volume. The comparatively large volume of tephra, the high eruptive columns, and high mass eruption rates make Sunset Crater the most explosive monogenetic eruption studied to date (volcano explosivity index [VEI] 3–4). Sunset Crater volcano represents an interesting case of monogenetic volcanism in that its activity was characterized by highly explosive eruptive phases up to subplinian in scale and intermittent episodes of lava effusion that heavily affected prehistoric communities in the area. Explosive basaltic volcanism should be considered when assessing volcanic hazards in continental settings, such as in the western United States.〈/span〉
    Print ISSN: 0016-7606
    Electronic ISSN: 1943-2674
    Topics: Geosciences
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  • 6
    Publication Date: 2014-03-15
    Description: Gusev crater has long been considered the site of a lake early in Martian history, but the Mars Exploration Rover Spirit found no apparent evidence of lake deposits along its 7 km traverse from 2004 to 2010. Although outcrops rich in Mg-Fe carbonate, dubbed Comanche, were discovered in the Noachian-aged Columbia Hills, they were inferred to result from volcanic hydrothermal activity. We now find evidence that the alteration of the Comanche outcrops is consistent with evaporative precipitation of low-temperature, near-surface solutions derived from limited water-rock interaction with rocks equivalent to nearby outcrops called Algonquin. Additional observations show that the Algonquin outcrops are remnants of volcanic tephra that covered the Columbia Hills and adjacent plains well before emplacement of basalt flows onto the floor of Gusev crater. Water-limited leaching of formerly widespread Algonquin-like tephra deposits by ephemeral waters, followed by transport and evaporative precipitation of the fluids into the Comanche outcrops, can explain their chemical, mineralogical, and textural characteristics.
    Print ISSN: 0091-7613
    Electronic ISSN: 1943-2682
    Topics: Geosciences
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  • 7
    Publication Date: 2012-06-01
    Print ISSN: 0195-928X
    Electronic ISSN: 1572-9567
    Topics: Physics
    Published by Springer
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  • 8
    Publication Date: 2019-10-23
    Print ISSN: 1757-8981
    Electronic ISSN: 1757-899X
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by Institute of Physics
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  • 9
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