Publication Date:
2000-04-28
Description:
Memory T cells maintain their numbers for long periods after antigen exposure. Here we show that CD8+ T cells of memory phenotype divide slowly in animals. This division requires interleukin-15 and is markedly increased by inhibition of interleukin-2 (IL-2). Therefore, the numbers of CD8+ memory T cells in animals are controlled by a balance between IL-15 and IL-2.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ku, C C -- Murakami, M -- Sakamoto, A -- Kappler, J -- Marrack, P -- AI-17134/AI/NIAID NIH HHS/ -- AI-18785/AI/NIAID NIH HHS/ -- AI-22295/AI/NIAID NIH HHS/ -- etc. -- New York, N.Y. -- Science. 2000 Apr 28;288(5466):675-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Department of Medicine, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, CO 80206, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10784451" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antibodies
;
Antigens, CD44/analysis
;
CD8-Positive T-Lymphocytes/*cytology/*immunology/transplantation
;
Cell Death
;
Cell Division
;
Homeostasis
;
*Immunologic Memory
;
Interleukin-15/immunology/*physiology
;
Interleukin-2/immunology/*physiology
;
Interleukin-7/immunology/physiology
;
Lymphocyte Count
;
Mice
;
Mice, Inbred C57BL
;
Phenotype
;
Receptors, Interleukin-15
;
Receptors, Interleukin-2/analysis/immunology
;
Receptors, Interleukin-7/immunology/physiology
;
Specific Pathogen-Free Organisms
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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