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  • 1
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    Structure of a human monoclonal antibody Fab fragment against gp41 of human immunodeficiency virus type 1 (1992)
    In:  Other Sources
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    Publication Date: 2019-08-28
    Description: The three-dimensional structure of a human monoclonal antibody (Fab), which binds specifically to a major epitope of the transmembrane protein gp41 of the human immunodeficiency virus type 1, has been determined by crystallographic methods to a resolution of 2.7 A. It has been previously determined that this antibody recognizes the epitope SGKLICTTAVPWNAS, belongs to the subclass IgG1 (kappa), and exhibits antibody-dependent cellular cytotoxicity. The quaternary structure of the Fab is in an extended conformation with an elbow bend angle between the constant and variable domains of 175 deg. Structurally, four of the hypervariable loops can be classified according to previously recognized canonical structures. The third hypervariable loops of the heavy (H3) and light chain (L3) are structurally distinct. Hypervariable loop H3, residues 102H-109H, is unusually extended from the surface. The complementarity-determining region forms a hydrophobic binding pocket that is created primarily from hypervariable loops L3, H3, and H2.
    Keywords: LIFE SCIENCES (GENERAL)
    Type: National Academy of Sciences, Proceedings (ISSN 0027-8424); p. 7154-7158.
    Format: text
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    NASA TECHNICAL REPORTS
  • 2
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    Hybrid state-space self-tuning control using dual-rate sampling (1991)
    In:  Other Sources
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    Publication Date: 2019-07-12
    Description: This paper presents a hybrid state-space self-tuning control scheme using dual-rate sampling for suboptimal digital adaptive control of linear time-invariant continuous-time multivariable stochastic systems with unknown parameters. An equivalent fast-rate discrete-time state-space innovation model (with estimated states) of the continuous-time system is constructed by using the estimated system parameters and Kalman gain. To utilize the existing optimal regional-pole assignment method developed in the continuous-time domain, the constructed fast-rate discrete-time model is converted into an equivalent continuous-time model for the development of a state-feedback optimal control law with pole placement in a specific region. The developed analog optimal control law is then converted into an equivalent pseudo-slow-rate digital control law via the proposed digital redesign technique, which can be realized via slow-rate digital electronics. The proposed method enables the development of a digitally implementable advanced control algorithm for digital adaptive control of continuous-time multivariable stochastic systems which may be unstable and/or have nonminimum phase.
    Keywords: CYBERNETICS
    Type: IEE Proceedings, Part D - Control Theory and Applications (ISSN 0143-7054); 138; 1 Ja
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    NASA TECHNICAL REPORTS
  • 3
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    Atomic structure and chemistry of human serum albumin (1992)
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    Publication Date: 2019-08-27
    Description: The three-dimensional structure of human serum albumin has been determined crystallographically to a resolution of 2.8 A. It comprises three homologous domains that assemble to form a heart-shaped molecule. Each domain is a product of two subdomains that possess common structural motifs. The principal regions of ligand binding to human serum albumin are located in hydrophobic cavities in subdomains IIA and ILIA, which exhibit similar chemistry. The structure explains numerous physical phenomena and should provide insight into future pharmacokinetic and genetically engineered therapeutic applications of serum albumin.
    Keywords: LIFE SCIENCES (GENERAL)
    Type: Nature (ISSN 0028-0836); 358; 6383; p. 209-215.
    Format: text
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    NASA TECHNICAL REPORTS
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