ISSN:
1662-9752
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
Recently, there has been an increasing interest in magnesium as biomaterials due to itssimilar elastic modulus, density and strength to that of human bone than other currently popularlyused metallic biomaterials. However, the knowledge of its biocompatibility is lacking. This paperreports the results of testing the cytotoxicity, haemolysis and acute toxicity on untreated and treatedmagnesium samples. The results showed that no cytotoxicity was detected on untreated magnesiumsamples. However, samples of alkali-treated magnesium caused distinct morphological changes oncells with a reduction in cell number vs the control group. In haemolysis tests, untreated magnesiumshowed a haemolytic effect, whereas there was a small haemolytic effect (2.2%) on alkali heat-treatedmetal; this is less than the allowable 5%. Magnesium samples coated with an organic film show thelowest haemolytic effect. No acute toxicity was observed; no animal deaths occurred and weobserved no obvious weight differences in untreated magnesium vs organic coated samples comparedto the control group
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/02/16/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.546-549.459.pdf
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