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Sensitivity of Ca2+ Transport of Mitochondria to Reactive Oxygen Species (1997)

Yang, Zhi-wei ; Yang, Fu-yu

Springer

Bioscience reports 17 (1997), S. 557-567

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ISSN: 1573-4935

Keywords: Reactive oxygen species (ROS) ; mitochondria ; Ca2+ transport ; energy transduction ; electron paramagnetic resonance (EPR)

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Chemistry and Pharmacology

Notes: Abstract The relationship between Ca2+ transport and energy transduction of myocardial mitochondria in the presence of reactive oxygen species was investigated. Following treatment with oxygen free radicals [superoxide(O 2 • ) or hydroxyl radical (•)OH], lipid free radicals in myocardial mitochondrial membrane could be detected by using the method of EPR spin trap. Simultaneously there were obvious alterations in the free Ca2+ ([Ca2+]m) in the mitochondrial matrix; the physical state of membrane lipid; the efficiency of oxidative phosphorylation (ADP/O); the value of the respiratory control ratio (RCR); and the membrane potential of the inner membrane of myocardial mitochondria. If the concentrations of reactive oxygen species were reduced by about 30%, the alterations in the physical state of the membrane lipid and energy transduction of myocardial mitochondria were not observed, but the changes in Ca2+ homeostasis remained. We conclude that Ca2+ transport by myocardial mitochondria is more sensitive to agents such as (O 2 • ) or •OH, etc. than are oxidation phosphorylation and the respiratory chain.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1023/A:1027316424985

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Synthesis and Characterization of (Z)-1-[2-(Triarylstannyl)vinyl]-1-Cyclohexanols and their Arylhalostannyl DerivativesDedicated to Professor Friedo Huber on his 65th Birthday (1994)

Xin, Fu Fang ; Lin, Shan Xi ; Jie, Fu Yu ; [et al.]

Weinheim : Wiley-Blackwell

Zeitschrift für anorganische Chemie 620 (1994), S. 1006-1010

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ISSN: 0044-2313

Keywords: Arylhalostannyl compounds ; syntheses ; characterization ; Chemistry ; Inorganic Chemistry

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Description / Table of Contents: Synthese und Charakterisierung von (Z)-1-[2-(Triarylstannyl)vinyl]-1-cyclohexanolen und ihren Arylhalostannyl-Derivaten1-Ethynyl-1-cyclohexanol reagiert mit Triarylzinn-Hydrid Ar3SnH (Ar = Phenyl, p-Tolyl) und bildet das entsprechende (Z)-1-[2-(Triarylstannyl)vinyl]-1-cyclohexanol. Das erhaltene Produkt reagiert mit ein oder zwei Äquivalenten Halogen (ICl oder I2) unter Bildung von (Z)-1-[2-(Diarylhalostannyl)vinyl]-1-cyclohexanol bzw. (Z)-1-[2-(Aryldihalostannyl)vinyl]-1-cyclohexanol. Alle Verbindungen wurden elementaranalytisch und durch 1H, 13C, 119Sn NMR und Mössbauer Spektroskopie charakterisiert.

Notes: 1-Ethynyl-1-cyclohexanol reacts with a triaryltin hydride Ar3SnH (Ar = phenyl, p-tolyl) and generates the corresponding (Z)-1-[2-(triarylstannyl)vinyl]-1-cyclohexanol. The product obtained reacts with one or two equivalents of halogen (ICl or I2) to form the associated (Z)-1-[2-(diarylhalostannyl)-vinyl]-1-cyclohexanol or (Z)-1-[2-(aryldihalostannyl)vinyl]-1-cyclohexanol, respectively. All compounds were characterized by elemental analysis, 1H, 13C, 119Sn NMR and Mössbauer spectroscopy.

Additional Material: 1 Ill.