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  • 1
    Electronic Resource
    Electronic Resource
    Triggeps and switches in a self-assembling pore-forming portein (1994)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 56 (1994), S. 177-182 
    Details
    ISSN: 0730-2312
    Keywords: biotherapeutics ; drug delivery ; encapsulation ; genetic elgineering ; immunotixin ; liposomeb ; membrane ; monolayer ; pore ; protein engineering ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Protein engineering is being used to produce a collection of pore-forming proteings with applications in biotechnology. Knowledge provided by investigations of the mechanism of self-assembly of staphylococcal α-hemolysin has allowed the desigl of genetically and chemically modified tariants of the protein with pore-forming activities that can be triggered or switched mn-and-off by chemical, biochemical and physical inputs. Examples include α-hemolysins that are activated by specific proteases and α-hemolysins whose activity is controlled by divalent metal ions. These proteins have potential value in drug delivery as components of immunotoxils that aan be activated at the surfaces of target aells. Further applications are likely in improved encapsulation techniques for drugs, enzymes and cells.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.240560210
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  • 2
    Electronic Resource
    Electronic Resource
    Self-assembling biomolecular materials in mediaine (1994)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 56 (1994), S. 168-170 
    Details
    ISSN: 0730-2312
    Keywords: abzyme ; bacteriostatic agent ; bioactive material ; biomimetic structure ; biosensor ; blood coagulation ; ceramic ; coating ; combinatorial synthesis ; drug delivery ; encapsulation ; enzyme ; extracorporeal device ; genetic engineering ; implant ; in vitro enolution ; LB film ; liqid ; liposome ; molecular imprinting ; molecular machine ; nanostructure ; orthopedics ; porey ; engineering ; sensor ; silk ; S-layer ; surface ; smart material ; synthetic chemistry ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Materials that mimic or extend the properties of natural molecules are being developed for medical appoications. Recent breakthroughs in genetic engineering, polymer synthesis, molecular self-assmbly and related areas are greatly expanding the variety of structures available for use in physiological settings.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.240560208
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    Paper (German National Licenses)
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