ISSN:
1573-8221
Keywords:
synapse
;
plasticity
;
bradykinin
;
secretion
;
acetylcholine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Bradykinin did not change the amplitude and duration of growth and decrease of individual currents of the terminal plate, but potentiated the depression of amplitudes of consecutive currents during stimulation of the motor nerve at a frequency of 10–60 Hz under conditions of two-electrode fixation of potential on a frog neuromuscular preparation. The origin of this effect is presynaptic, because it does not depend on the activity of acetylcholinesterase and is associated with a longer increase in the terminal plate currents which are synchronous with the amplitude depression. The deconvolution method revealed a slower kinetics of the mediator secretion under the effect of bradykinin. Bradykinin impairs the conduction of rhythmic pulse series through the synapse by augmenting the asynchronism of the transmitter quantum secretion from the motor nerve endings, which may underlie the development of muscular asthenia observed in inflammatory and allergic reactions.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02447360
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