ISSN:
0947-3440
Keywords:
7-Nitro-7-deaza-2′ -deoxyadenosine
;
8-Methyl-7-deaza-2′ -deoxyguanosine
;
Conformation analysis
;
X-ray scattering
;
NMR spectroscopy
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The crystal structures of 7-nitro-7-deaza-2′ -deoxyadenosine (3) and 8-methyl-7-deaza-2′ -deoxyguanosine (5) have been determined and were compared with those of the parent 7-deaza-2′ -deoxyadenosine (2) and other 7-substituted 7-deazapurine 2′ -deoxynucleosides 4 and 6. The sugar pucker of compound 3 is N (3′T2′) whereas compound 5 shows 2′E conformation (S-type). Despite the methyl group, compound 5 exhibits anti conformation about the N-glycosylic bond as in all other cases. The predominant conformations of 3 and 5 in aqueous solution, determined by 1H NMR spectroscopy, is consistent with those in the solid state.
Additional Material:
8 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.199719971215
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