Publication Date:
2009-04-25
Description:
Throughout the day, cognitive performance is under the combined influence of circadian processes and homeostatic sleep pressure. Some people perform best in the morning, whereas others are more alert in the evening. These chronotypes provide a unique way to study the effects of sleep-wake regulation on the cerebral mechanisms supporting cognition. Using functional magnetic resonance imaging in extreme chronotypes, we found that maintaining attention in the evening was associated with higher activity in evening than morning chronotypes in a region of the locus coeruleus and in a suprachiasmatic area (SCA) including the circadian master clock. Activity in the SCA decreased with increasing homeostatic sleep pressure. This result shows the direct influence of the homeostatic and circadian interaction on the neural activity underpinning human behavior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schmidt, Christina -- Collette, Fabienne -- Leclercq, Yves -- Sterpenich, Virginie -- Vandewalle, Gilles -- Berthomier, Pierre -- Berthomier, Christian -- Phillips, Christophe -- Tinguely, Gilberte -- Darsaud, Annabelle -- Gais, Steffen -- Schabus, Manuel -- Desseilles, Martin -- Dang-Vu, Thien Thanh -- Salmon, Eric -- Balteau, Evelyne -- Degueldre, Christian -- Luxen, Andre -- Maquet, Pierre -- Cajochen, Christian -- Peigneux, Philippe -- New York, N.Y. -- Science. 2009 Apr 24;324(5926):516-9. doi: 10.1126/science.1167337.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cyclotron Research Centre, University of Liege, 4000 Liege, Belgium. Christina.Schmidt@ulg.ac.be〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19390047" target="_blank"〉PubMed〈/a〉
Keywords:
Attention/*physiology
;
Brain Mapping
;
Circadian Rhythm
;
Cognition/*physiology
;
Female
;
Homeostasis/*physiology
;
Humans
;
Magnetic Resonance Imaging
;
Male
;
Melatonin/metabolism
;
Polysomnography
;
Psychomotor Performance
;
Sleep/*physiology
;
Suprachiasmatic Nucleus/*physiology
;
Thalamus/physiology
;
Wakefulness
;
Young Adult
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
