Publication Date:
1993-11-05
Description:
B7 delivers a costimulatory signal through CD28, resulting in interleukin-2 secretion and T cell proliferation. Blockade of this pathway results in T cell anergy. The in vivo role of B7 was evaluated with B7-deficient mice. These mice had a 70 percent decrease in costimulation of the response to alloantigen. Despite lacking B7 expression, activated B cells from these mice bound CTLA-4 and GL1 monoclonal antibody, demonstrating that alternative CTLA-4 ligand or ligands exist. These receptors are functionally important because the residual allogenic mixed lymphocyte responses were blocked by CTLA4Ig. Characterization of these CTLA-4 ligands should lead to strategies for manipulating the immune response.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Freeman, G J -- Borriello, F -- Hodes, R J -- Reiser, H -- Hathcock, K S -- Laszlo, G -- McKnight, A J -- Kim, J -- Du, L -- Lombard, D B -- CA 40216/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1993 Nov 5;262(5135):907-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Boston, MA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7694362" target="_blank"〉PubMed〈/a〉
Keywords:
Abatacept
;
Animals
;
Antigens, CD
;
Antigens, CD80/genetics/*immunology/metabolism
;
Antigens, Differentiation/immunology/*metabolism
;
B-Lymphocytes/*immunology
;
Base Sequence
;
CTLA-4 Antigen
;
Cell Line
;
*Immunoconjugates
;
Interleukin-2/secretion
;
Isoantigens/immunology
;
Lymphocyte Activation
;
Lymphocyte Culture Test, Mixed
;
Mice
;
Mice, Inbred BALB C
;
Mice, Inbred C57BL
;
Mice, Knockout
;
Molecular Sequence Data
;
Mutation
;
T-Lymphocytes/*immunology
;
Transfection
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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