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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of experimental biology and medicine 88 (1979), S. 1041-1044 
    ISSN: 1573-8221
    Keywords: Mycoplasma arthritidis ; Acholeplasma laidlawii ; Rauscher leukemia virus ; immune response
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Mixed infection of hybrid mice, highly resistant to Rauscher virus, with this virus andMycoplasma arthritidis was accompanied by progressive inhibition of populations of splenic rosetteforming (REC) and plaque-forming (PFC) cells and led to induction of malignant erythroblastosis, cytologically identical with Rauscher's leukemia. During mixed infection of the hybrid mice withAcholeplasma laidlawii and Rauscher virus the immune response was almost completely suppressed on the 21st day and considerable splenomegaly was observed, but by the 62nd day of infection the RFC and PFC populations and also the weight of the spleens had regained the control level. The possible role of mycoplasmas in the induction and development of Rauscher's leukemia is discussed.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-8221
    Keywords: mycoplasma ; Rauscher virus ; endogenous colonies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Mycoplasma arthritidis was shown not to affect endogenous colony formation in lethally irradiated BALB/c mice. The number of endogenous foci in mice irradiated in sublethal doses and infected withM. arthritidis was sharply increased when the mycoplasma was injected 24 h before or 4 h after irradiation. Mixed infection of (C57BL/6×A/Sn)F1 mice resistant to Rauscher virus with this virus and mycoplasma led to a marked increase in the number of endogenous colonies in the early stages of infection. This phenomenon may perhaps lie at the basis of the loss of resistance in the hybrid mice and the appearance of leukemia in them as a result of mixed infection with mycoplasma and virus.
    Type of Medium: Electronic Resource
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