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  • 1
    Electronic Resource
    Electronic Resource
    Swelling kinetics and release characteristic of crosslinked chitosan: Polyether polymer network (semi-IPN) hydrogels (1994)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 32 (1994), S. 1213-1223 
    Details
    ISSN: 0887-624X
    Keywords: chitosan ; semi-IPN hydrogel ; swelling kinetics ; pH-sensitivity ; controlled release ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The aqueous swelling kinetics of a series of crosslinked chitosan (cr-CS) with glutaraldehyde (GA) interpenetrating polyether hydrogels have been studied as functions of pH, the N-deacetylation degree of chitosan, the amount of crosslinking agent, the electrolyte composition in solution, temperature, and gel composition. Based on these results, the swelling mechanism of the hydrogels was discussed. The release profiles of chlorhexidini acetas from the semi-IPN were also investigated. © 1994 John Wiley & Sons, Inc.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pola.1994.080320702
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  • 2
    Electronic Resource
    Electronic Resource
    Proteinlike molecular architecture: Biomaterial applications for inducing cellular receptor binding and signal transduction (1998)
    New York : Wiley-Blackwell
    Biopolymers 47 (1998), S. 143-151 
    Details
    ISSN: 0006-3525
    Keywords: molecular architecture ; biomaterials ; tissue engineering ; cellular receptor binding ; signal transduction ; endothelial cell attachment ; thrombosis ; self-assembly ; peptide-amphiphile ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The development of biomaterials with desirable biocompatibility has presented a difficult challenge for tissue engineering researchers. First and foremost, materials themselves tend to be hydrophobic and/or thrombogenic in nature, and face compatibility problems upon implantation. To mediate this problem, researchers have attempted to graft proteins or protein fragments onto biomaterial surfaces to promote endothelial cell attachment and minimize thrombosis. We envisioned a novel approach, based on the capability of biomolecules to self-assemble into well-defined and intricate structures, for creating biomimetic biomaterials that promote cell adhesion and proliferation. One of the most intriguing self-assembly processes is the folding of peptide chains into native protein structures. We have developed a method for building proteinlike structural motifs that incorporate sequences of biological interest. A lipophilic moiety is attached onto an Nα-amino group of a peptide chain, resulting in a “peptide-amphiphile.” The alignment of amphiphilic compounds at the lipid-solvent interface is used to facilitate peptide alignment and structure initiation and propagation, while the lipophilic region adsorbs to hydrophobic surfaces. Peptide-amphiphiles containing potentially triple-helical or α-helical structural motifs have been synthesized. The resultant head group structures have been characterized by CD spectroscopy and found to be thermally stable over physiological temperature ranges. Triple-helical peptide-amphiphiles have been applied to studies of surface modification and cell receptor binding. Cell adhesion and spreading was promoted by triple-helical peptide-amphiphiles. Cellular interaction with the type IV collagen sequence α1(IV) 1263-1277 increased signal transduction, with both the time and level of induction dependent upon triple-helical conformation. Collectively, these results suggest that peptide-amphiphiles may be used to form stable molecular structures on biomaterial surfaces that promote cellular activities and improve biocompatibility. © 1998 John Wiley & Sons, Inc. Biopoly 47: 143-151, 1998
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of aromatic diamine extenders on the morphology and property of RIM polyurethane-urea (1994)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 53 (1994), S. 23-29 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: An aromatic diamine, CMOMDA, was synthesized and used as a chain extender for reaction injection molding (RIM) polyurethane-urea. The morphology and properties of CMOMDA-, DETDA-, and MDA-extended poly(ether-urethane-urea)s (PEUUs) were measured by IR, DSC, DMS, SEM, and tensile testing apparatus. Well-matched values of Ch and Xut,b/Ch were necessary for aromatic diamine-extended PEUU. DSC and SEM showed that the aggregation state of hard segments might undergo some changes with increasing hard-segment content. © 1994 John Wiley & Sons, Inc.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1994.070530103
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