Publication Date:
2010-12-24
Description:
Using DNA extracted from a finger bone found in Denisova Cave in southern Siberia, we have sequenced the genome of an archaic hominin to about 1.9-fold coverage. This individual is from a group that shares a common origin with Neanderthals. This population was not involved in the putative gene flow from Neanderthals into Eurasians; however, the data suggest that it contributed 4-6% of its genetic material to the genomes of present-day Melanesians. We designate this hominin population 'Denisovans' and suggest that it may have been widespread in Asia during the Late Pleistocene epoch. A tooth found in Denisova Cave carries a mitochondrial genome highly similar to that of the finger bone. This tooth shares no derived morphological features with Neanderthals or modern humans, further indicating that Denisovans have an evolutionary history distinct from Neanderthals and modern humans.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306417/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306417/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reich, David -- Green, Richard E -- Kircher, Martin -- Krause, Johannes -- Patterson, Nick -- Durand, Eric Y -- Viola, Bence -- Briggs, Adrian W -- Stenzel, Udo -- Johnson, Philip L F -- Maricic, Tomislav -- Good, Jeffrey M -- Marques-Bonet, Tomas -- Alkan, Can -- Fu, Qiaomei -- Mallick, Swapan -- Li, Heng -- Meyer, Matthias -- Eichler, Evan E -- Stoneking, Mark -- Richards, Michael -- Talamo, Sahra -- Shunkov, Michael V -- Derevianko, Anatoli P -- Hublin, Jean-Jacques -- Kelso, Janet -- Slatkin, Montgomery -- Paabo, Svante -- R01 GM040282/GM/NIGMS NIH HHS/ -- R01-GM40282/GM/NIGMS NIH HHS/ -- England -- Nature. 2010 Dec 23;468(7327):1053-60. doi: 10.1038/nature09710.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA. reich@genetics.med.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21179161" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Asia
;
DNA, Mitochondrial/genetics
;
Europe
;
Finger Phalanges/chemistry
;
*Fossils
;
*Gene Flow
;
Genome/*genetics
;
Hominidae/*classification/*genetics
;
Humans
;
Melanesia
;
Molecular Sequence Data
;
Phylogeny
;
Siberia
;
Tooth/anatomy & histology/chemistry
Print ISSN:
0028-0836
Electronic ISSN:
1476-4687
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
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