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Phenindamine and its analogues and precursors: NMR evidence of structure and configuration (1992)

Casy, Alan F. ; Hussain, Rohannah B. ; Upton, Christopher

Chichester : Wiley-Blackwell

Organic Magnetic Resonance 30 (1992), S. 621-625

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ISSN: 0749-1581

Keywords: Phenindamine Antihistamines Di ; tetra- and hexahydro-1-pyrindenes 1H and 13C NMR ; Chemistry ; Analytical Chemistry and Spectroscopy

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: The 1H and 13C NMR spectra of analogues of the antihistaminie agent phenindamine and its precursors are interpreted in terms of structure and geometry. Points of interest are the conformations of 4-piperidinol and dihydro-1-pyrindene(diene) intermediates, and the configuration of the hexahydro analogue of phenindamine and its corresponding product of equilibration. Results of an antihistamine evaluation test are presented.

Additional Material: 5 Tab.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1002/mrc.1260300708

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