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  • 1
    Electronic Resource
    Electronic Resource
    The effect of probenecid on paracetamol metabolism and pharmacokinetics (1993)
    Springer
    European journal of clinical pharmacology 45 (1993), S. 551-553 
    Details
    ISSN: 1432-1041
    Keywords: Paracetamol ; Probenecid ; drug metabolism ; drug interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The influence of probenecid on the pharmacokinetics of paracetamol was investigated in a group of healthy volunteers. Pretreatment with probenecid caused a significant decrease in paracetamol clearance (6.23 to 3.42 ml·min−1·kg−1). The urinary excretion of paracetamol sulphate (243 to 193 mg); and paracetamol glucuronide (348 to 74.5 mg) were significantly reduced, whereas that of paracetamol was unchanged. Probenecid was shown to be an uncompetitive inhibitor of paracetamol glucuronidation in vitro, using rat liver microsomes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315313
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