ISSN:
1432-1432
Keywords:
Genome composition
;
Isochores
;
Neutral theory
;
Natural selection
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary Nucleotide sequences of all genomes are subject to compositional constraints that (1) affect, to about the same extent, both coding and noncoding sequences; (2) influence not only the structure and function of the genome, but also those of transcripts and proteins; (3) are the result of environmental pressures; and (4) largely control the fixation of mutations. These findings indicate (1) that noncoding sequences are associated with biological functions; (2) that the organismal phenotype comprises two components, the classical phenotype, corresponding to the “gene products,” and a “genome phenotype,” which is defined by the compositional constraints; and (3) that natural selection plays a more important role in genome evolution than do random events.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02099946
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