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  • 1
    Electronic Resource
    Electronic Resource
    Structure of Neuritogenic Active Ganglioside from the Sea Cucumber   Stichopus japonicus (1999)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1999 (1999), S. 3171-3174 
    Details
    ISSN: 1434-193X
    Keywords: Glycosphingolipid ; Ganglioside ; Sea cucumber ; Stichopus japonicus ; Neuritogenic activity ; Natural products ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A ganglioside molecular species SJG-1 has been obtained from the n-hexane soluble lipid fraction of the chloroform/methanol extract of the sea cucumber Stichopus japonicus. On the basis of chemical and spectroscopic evidence, the structure of SJG-1 has been determined. SJG-1 possesses an N-glycolylneuraminic acid (sialic acid), nonhydroxy fatty acids and phytosphingosine-type long-chain bases as major ceramide components. The ganglioside SJG-1 exhibits neuritogenic activity toward the rat pheochromocytoma cell line PC12 cells in the presence of NGF.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
  • 2
    Electronic Resource
    Electronic Resource
    Isolation and Structure of Biologically Active Gangliosides from the Sea Cucumber Holothuria pervicax (1998)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1998 (1998), S. 2519-2525 
    Details
    ISSN: 1434-193X
    Keywords: Glycosphingolipids ; Gangliosides ; Sea cucumber ; Holothuria pervicax ; Neuritogenic activity ; Natural products ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Three ganglioside molecular species, HPG-8, HPG-3, and HPG-1, have been obtained from the polar fraction of the chloroform/methanol extract of the sea cucumber Holothuriapervicax. The structures of these gangliosides have been determined on the basis of chemical and spectroscopic evidence. They represent new ganglioside molecular species. HPG-8 is a sulfated monosialo-ganglioside, while HPG-3 and HPG-1 are disialo-gangliosides possessing 2→4-linked tandem-type disialosyl moieties. These three gangliosides qualitative neuritogenic activity toward the rat pheochromocytoma cell line, PC-12 cells.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Partial Synthesis of a Sea Cucumber Ganglioside Analogue from a Starfish Cerebroside (1999)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1999 (1999), S. 145-147 
    Details
    ISSN: 1434-193X
    Keywords: Natural products ; Ganglioside ; Cerebroside ; Sphingolipids ; Echinoderms ; Sea cucumber ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: -A sea cucumber ganglioside analogue 7 (NGNAα2→ 6Glcβ1→1Cer), which contains a phytosphingosine as a long-chain base and an α-hydroxy fatty acid, has been synthesized. Coupling of the methyl 2-thioglycoside derivative 5 of N-glycolylneuraminic acid with a cerebroside derivative 3, prepared from acanthacerebroside A (1), afforded protected ganglioside analogue 6, which was deprotected to give the corresponding ganglioside 7.
    Type of Medium: Electronic Resource
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