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  • 1
    ISSN: 1432-1041
    Keywords: NSAID ; Gastrotoxicity ; gastroscopy ; healthy volunteers ; ibuprofen ; ketoprofen ; aspirin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Endoscopic lesions of the gastric mucosa were evaluated in 12 healthy volunteers after administration of single doses of ketoprofen (25 mg), ibuprofen (200 mg) and aspirin (500 mg) in a randomized, double-blind, crossover study. The grades of the lesions (according to Lanza's scale) were lower after the administration of ketoprofen than aspirin and were comparable to ibuprofen. An endoscopic score 〉1 was observed in 3 cases after ibuprofen or ketoprofen, and in 8 cases after aspirin. At a time when low, single doses of NSAIDs are widely used as analgesics, gastroscopy makes it possible directly to assess the local agressivity of these molecules. In this way it was possible to demonstrate that the local toxicity of NSAIDs was lower than that of aspirin.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 25 (1994), S. 3-10 
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Transferability - a fundamental problem for fatigue life predictionFrequently specimen fatigue data have to be applied for fatigue life assessment of components and structures. It has to be assured that such data are relevant for the component under consideration. Equally it has to be assured that constant amplitude S-N data can be used for fatigue assessment in the case of spectrum loading. It is shown that application of transfer functions which are often of empirical nature requires an understanding of basic principles of material and component behaviour. Life prediction concepts should acknowledge the existence and relative portion of the crack initiation and crack propagation phases which are dominated by different mechanisms.
    Notes: Die Übertragbarkeit von Probestabschwingfestigkeitskennwerten auf Bauteile stellt eine wesentliche Voraussetzung für die Lebensdauervorhersage dar. Dies betrifft ebenso die Übertragung von Kennwerten für einstufige Schwingbelastung auf regellose Belastungsfälle im Rahmen der Schadensakkumulationsrechnung. Es wird aufgezeigt, daß bei der Anwendung der häufig empirisch gewonnenen Übertragungskennwerte und -funktionen die werkstoffmechanischen Grundlagen und Einschränkungen beachtet werden müssen, um Fehlschlüsse zu vermeiden. Insbesondere sollten Anriß- und Rißfortschrittsphase getrennt betrachtet werden, da hier unterschiedliche und teilweise gegenläufige Mechanismen dominieren.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 8 (1977), S. 89-100 
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: On some recent crack initiation life prediction procedures for cyclic loaded members based on local material behaviourA critical review of some recently suggested procedures is given. Distinction is made between the procedure according to the basic scheme and the modified procedures. The first one is based on three fundamentals - Load-Notch Strain Relation, - Stress-Strain Law of the Material, - Damage and Failure of the Material. The modified procedures additionally take into account the cyclic behavior of the member. The modified procedures additionally take into account the cyclic behavior of the member. The three fundamentals are described, especially the two latter concerning material behavior. The transferability of this behavior as investigated by means of smooth specimens to that of the notch root element is discussed briefly. The various procedures are explained and the quality of their modifications is reviewed. Finally possible improvements of the three fundamentals and of the transferability are pointed out. Modifications should only be made within those fundamentals, where results of the calculation according to the basic scheme deviate from experimental results. In order to find the deviations, each fundamental must be checked separately.
    Notes: Es wird ein kritischer Überblick über die derzeit bekannten neueren Berechnungsverfahren gegeben. Unterschieden wird zwischen dem Verfahren nach dem Grundschema und den modifizierten Verfahren. Das erstere arbeitet auf der Grundlage der drei Bausteine - „Gesetzmäßigkeit für den Zusammenhang zwischen äußerer Belastung und Kerbgrundbeanspruchung“, - „zyklisches Spannungs- Dehnungsverhalten des Werkstoffes“ und - „Schädigung und Versagen des Werkstoffes“. Die modifizierten Verfahren verwenden zusätzlich Kenntnisse über das zyklische Bauteilverhalten. Zunächst werden die drei Bausteine, insbesondere die beiden letzten, die das Werkstoffverhalten betreffen, eingehend beschrieben. Danach wird die Frage nach der Übertragbarkeit des an glatten Proben ermittelten Werkstoffverhaltens auf das Verhalten des Kerbgrundelementes erörtert. Die Berechnungsverfahren werden erläutert und bewertet. Zum Abschluß werden Verbesserungsmöglichkeiten aufgezeigt, die die drei Bausteine sowie die Übertragbarkeit betreffen. Es wird gefordert, daß bei den modifizierten Verfahren die Modifikationen nur in den Bausteinen vorgenommen werden, in denen bei der Rechnung nach dem Grundschema Fehler entstehen. Der Nachweis solcher Fehler muß durch die Überprüfung der einzelnen Bausteine erbracht werden.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    New York : Wiley-Blackwell
    Journal of Polymer Science: Polymer Chemistry Edition 15 (1977), S. 983-989 
    ISSN: 0360-6376
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A new solvent system comprising a mixture of nitrobenzene and tetrachloroethane has been developed for determining the molecular size distribution of poly(ethylene terephthalate) (PET) by gel-permeation chromatography (GPC). Unlike hot m-cresol, which until now has been the standard GPC solvent for PET, the nitrobenzene-tetrachloroethane mixture can be used at room temperature and thus minimizes polymer degradation and distribution equilibration. Results with this new system reveal reproducibly discernible differences between PET samples prepared by melt and solid-state polymerization, differences not previously noted in GPC reports based on the use of m-cresol.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Acta Polymerica 32 (1981), S. 221-224 
    ISSN: 0323-7648
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Starting from problems of process modelling by dimensionsless parameters the flow characteristics of viscoelastic liquids were derived. The rheological equations of state are differential models and they are used for shear and elongational flow. Three independend functions are deduced from the rheological equations of state.
    Notes: Ausgehend von Problemen der Prozeßmodellierung mit dimensionslosen Kenngrößen wurden Kenngrößen für die Strömung viskoelastischer Flüssigkeiten hergeleitet. Als Stoffgesetz wurden Differentialmodelle und als Strömungen die Scher- und die Dehnströmung verwendet. Die rheologische Zustandsgleichung wird in drei unabhängige Funktionen umgeformt.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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