ISSN:
1432-0878
Keywords:
Key words: Degranulation
;
Pancreas
;
Golgi complex
;
Pilocarpine
;
Unit granule formation
;
Mouse (ICR)
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract. We used a computer-assisted morphometry approach to analyze quantitatively the process of cytoplasmic granule formation in mouse pancreatic acinar cells stimulated with pilocarpine to induce secretion. Our findings suggest that each condensing vacuole/immature granule of pancreatic acinar cells is formed by the progressive aggregation of 106 to 128 “unit progranules” of narrowly fixed volume, define a range of 7.7 to 9.2 for the factor of volume condensation between the largest immature granules and the mature unit granule, and predict that the formation of a single mature unit granule by the aggregation and fusion of unit progranules involves a net reduction of at least 95% in the amount of membrane surface area associated with these structures.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00414176
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