ISSN:
1573-4951
Keywords:
β 2-Adrenergic receptor
;
Noradrenaline
;
Drug-receptor interactions
;
Molecular graphics
;
Molecular mechanics
;
Semi-empirical molecular orbital calculations
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary A model of theβ 2-adrenergic receptor binding site is built from the primary structure of the receptor, experimental evidence for key binding residues and analogy with a homologous protein of partially determined structure. It is suggested that residues Trp-109, Thr-110 and Asp-113 are involved in ligand binding. Noradrenaline is successfully docked into this model, and the results of an INDO molecular orbital calculation on the complex indicate that a charge transfer interaction between Trp-109 and noradrenaline is possible.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01533069
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