ISSN:
1432-041X
Keywords:
Drosophila melanogaster
;
Dosage compensation
;
Male-specific lethal mutations
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary The male-specific lethal genes (msl) of D. melanogaster represent a set of genes whose functions are required for the specific X chromosome hypertranscription in males (dosage compensation). We have carried out the clonal analysis of one of those msl mutations: msl-3 b. Clones homozygous for msl-3 b are deleterious; this mutation presents cell autonomy and in the cases where msl clones appeared in sexually dimorphic regions (5th and 6th tergites) they do not show sexual transformation. Moreover, the lethal phase and the growth dynamics (measured by the protein content during larval growth) are the same for male larvae homozygous for one msl mutation (msl-1) or three msl mutations (msl-2 msl-1 mle), i.e. the msl mutations do not show additive effects. This paper considers the possible interactions between the msl genes that bring about dosage compensation.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00376368
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