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Immunotherapeutic use of neuraminidase in chemically induced carcinogenesis (1977)

Maiskii, I. N. ; Airapet'yan, G. P. ; Kobrinskii, G. D. ; [et al.]

Springer

Bulletin of experimental biology and medicine 84 (1977), S. 1756-1759

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ISSN: 1573-8221

Keywords: chemical carcinogenesis ; neuraminidase ; immunotherapy

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Abstract The action of neuraminidase fromVibrio cholerae on the development of sarcomas induced in CBA mice by dimethylbenzanthracene was studied. Administration of the enzyme preparation began after the appearance of tumors in the animals. Administration of 50 units neuraminidase twice a week to the mice for 3 months was effective in the early stages of carcinogenesis. An increase in the survival period of the experimental mice compared with the control animals was observed after intraperitoneal injection of cells of a syngeneic induced sarcoma, and of injection of sensitized lymphocytes obtained from syngeneic mice with tumors into the region of the developing tumor. No positive effect was observed if lymphocytes injected into the region of the tumor were treated previously with neuraminidase. Simultaneous injection of neuraminidase into the region of the developing tumor and intraperitoneal injection of syngeneic induced sarcoma cells treated with the enzyme was particularly effective against carcinogenesis. The possibilities of the use of the enzyme neuraminidase under clinical conditions are discussed.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00804828

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Effects of microwave radiation (340 and 900 MHz) on different structural levels of erythrocyte membranes (1985)

Kim, Y. A. ; Fomenko, B. S. ; Agafonova, T. A. ; [et al.]

New York, NY [u.a.] : Wiley-Blackwell

Bioelectromagnetics 6 (1985), S. 305-312

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ISSN: 0197-8462

Keywords: 340 MHz and 900 MHz ; microwave radiation ; temperature ; fluoresence probes ; trinitrobenzene sulfonic acid ; erythrocytes ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology , Physics

Notes: By use of fluorescence probes 1-anilinonaphthalene-8-sulfonic acid, 2-toluidinylnaphthal-ene-6-sulfonate, pyrene, perylene and chemical label phosphatidylethanolamine 2,4,6-trinitrobenzele sulfonic acid, the effect of microwave radiation on the erythrocyte membrane was studied. The studies with the fluorescence probes were carried out on erythrocyte ghosts and with 2,4,6-trinitrobenzene sulfonic acid on whole erythrocytes. The fluorescence was measured during irradiation of the membranes with 340-MHz microwaves at an SAR of 100 W/kg. Trinitrophenylation of phosphatidylethanolamine from whole erythrocytes was performed simultaneously with microwave irradiation at 900 MHz (10 mW/cm2). It was shown that the microwave field decreased lipid viscosity, altered the structural state of lipid-protein contact regions, and decreased the protein shielding of lipids. These changes corresponded to those produced by thermal action of microwaves.

Additional Material: 4 Ill.