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Estimation of steady state antibiotic concentration in cerebrospinal fluid from single-dose kinetics (1996)

Nau, R. ; Prange, H. W.

Springer

European journal of clinical pharmacology 49 (1996), S. 407-409

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ISSN: 1432-1041

Keywords: Key words Antibiotics; cerebrospinal fluid kinetics ; AUC in CSF

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Abstract. Objective: Assuming linear kinetics, the mean CSF concentrations of an antibacterial in steady state (CssCSF) can be estimated, when the area under the concentration-time curve in CSF after the first dose is known. For this purpose we propose the function CssCSF = AUCCSF⋅Anticipated dose/Dosing Interval⋅Applied dose. Results: Together with the MIC and MBC of the causative pathogen, the estimate is of value in the choice of antibacterial drug and the dosing regimen in central nervous system infections.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s002280050041

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