Publication Date:
1982-10-29
Description:
Somatostatin perfused in canine pancreases at 10 to 20 picograms per milliliter or 10 to 20 percent of the pancreatic vein somatostatin concentration inhibited insulin and glucagon secretion. This suggests that the high local concentration of endogenous somatostatin is not in contact with somatostatin receptors of the islets. The integrity of this separation may determine the sensitivity of islet cells to circulating somatostatin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kawai, K -- Ipp, E -- Orci, L -- Perrelet, A -- Unger, R H -- New York, N.Y. -- Science. 1982 Oct 29;218(4571):477-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6126931" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Dogs
;
Dose-Response Relationship, Drug
;
Glucagon/secretion
;
Insulin/secretion
;
Intercellular Junctions/physiology
;
Islets of Langerhans/*secretion
;
Receptors, Cell Surface/physiology
;
Receptors, Somatostatin
;
Somatostatin/*blood/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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