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  • 1
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    Activation of the ATM kinase by ionizing radiation and phosphorylation of p53 (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-09-11
    Description: The p53 tumor suppressor protein is activated and phosphorylated on serine-15 in response to various DNA damaging agents. The gene product mutated in ataxia telangiectasia, ATM, acts upstream of p53 in a signal transduction pathway initiated by ionizing radiation. Immunoprecipitated ATM had intrinsic protein kinase activity and phosphorylated p53 on serine-15 in a manganese-dependent manner. Ionizing radiation, but not ultraviolet radiation, rapidly enhanced this p53-directed kinase activity of endogenous ATM. These observations, along with the fact that phosphorylation of p53 on serine-15 in response to ionizing radiation is reduced in ataxia telangiectasia cells, suggest that ATM is a protein kinase that phosphorylates p53 in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Canman, C E -- Lim, D S -- Cimprich, K A -- Taya, Y -- Tamai, K -- Sakaguchi, K -- Appella, E -- Kastan, M B -- Siliciano, J D -- CA71387/CA/NCI NIH HHS/ -- ES05777/ES/NIEHS NIH HHS/ -- New York, N.Y. -- Science. 1998 Sep 11;281(5383):1677-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Johns Hopkins School of Medicine, Oncology Center, Baltimore, MD 21205, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9733515" target="_blank"〉PubMed〈/a〉
    Keywords: Ataxia Telangiectasia Mutated Proteins ; Cell Cycle Proteins ; Cell Line ; DNA Damage ; DNA-Activated Protein Kinase ; *DNA-Binding Proteins ; Enzyme Activation ; Humans ; Lymphocytes/metabolism/radiation effects ; Mutation ; Nuclear Proteins ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphorylation ; Phosphoserine/metabolism ; Protein Kinases/*metabolism ; Protein-Serine-Threonine Kinases/metabolism ; Proteins/genetics/*metabolism ; *Radiation, Ionizing ; Recombinant Fusion Proteins/metabolism ; Recombinant Proteins/metabolism ; Signal Transduction ; Transfection ; Tumor Suppressor Protein p53/*metabolism ; Tumor Suppressor Proteins ; Ultraviolet Rays
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Attempt of Serendipitous Science During the Mojave Volatile Prospector Field Expedition (2015)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: On 23 October a partial solar eclipse occurred across parts of the southwest United States between approximately 21:09 and 23:40 (UT), with maximum obscuration, 36%, occurring at 22:29 (UT). During 21-26 October 2014 the Mojave Volatile Prospector (MVP) field expedition deployed and operated the NASA Ames Krex2 rover in the Mojave desert west of Baker, California (Fig. 1, bottom). The MVP field expedition primary goal was to characterize the surface and sub-surface soil moisture properties within desert alluvial fans, and as a secondary goal to provide mission operations simulations of the Resource Prospector (RP) mission to a Lunar pole. The partial solar eclipse provided an opportunity during MVP operations to address serendipitous science. Science instruments on Krex2 included a neutron spectrometer, a near-infrared spectrometer with associated imaging camera, and an independent camera coupled with software to characterize the surface textures of the areas encountered. All of these devices are focused upon the surface and as a result are downward looking. In addition to these science instruments, two hazard cameras are mounted on Krex2. The chief device used to monitor the partial solar eclipse was the engineering development unit of the Near-Infrared Volatile Spectrometer System (NIRVSS) near-infrared spectrometer. This device uses two separate fiber optic fed Hadamard transform spectrometers. The short-wave and long-wave spectrometers measure the 1600-2400 and 2300-3400 nm wavelength regions with resolutions of 10 and 13 nm, respectively. Data are obtained approximately every 8 seconds. The NIRVSS stares in the opposite direction as the front Krex2.
    Keywords: Instrumentation and Photography; Lunar and Planetary Science and Exploration
    Type: ARC-E-DAA-TN20328 , Lunar and Planetary Science Conference (LPSC); Mar 16, 2015 - Mar 20, 2015; The Woodlands, TX; United States
    Format: application/pdf
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