Publication Date:
2008-07-05
Description:
In the cerebral cortex, diverse types of neurons form intricate circuits and cooperate in time for the processing and storage of information. Recent advances reveal a spatiotemporal division of labor in cortical circuits, as exemplified in the CA1 hippocampal area. In particular, distinct GABAergic (gamma-aminobutyric acid-releasing) cell types subdivide the surface of pyramidal cells and act in discrete time windows, either on the same or on different subcellular compartments. They also interact with glutamatergic pyramidal cell inputs in a domain-specific manner and support synaptic temporal dynamics, network oscillations, selection of cell assemblies, and the implementation of brain states. The spatiotemporal specializations in cortical circuits reveal that cellular diversity and temporal dynamics coemerged during evolution, providing a basis for cognitive behavior.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4487503/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4487503/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klausberger, Thomas -- Somogyi, Peter -- MC_U138197107/Medical Research Council/United Kingdom -- MC_U138197110/Medical Research Council/United Kingdom -- MC_UU_12020/3/Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2008 Jul 4;321(5885):53-7. doi: 10.1126/science.1149381.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉MRC Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, UK. thomas.klausberger@pharm.ox.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18599766" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Axons/physiology
;
Biological Evolution
;
Cognition
;
Dendrites/physiology
;
Hippocampus/cytology/*physiology
;
Humans
;
Interneurons/*physiology
;
Nerve Net/*physiology
;
Neural Pathways/physiology
;
Neurons/*physiology
;
Pyramidal Cells/*physiology
;
Synapses/physiology
;
gamma-Aminobutyric Acid/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
