Publication Date:
2001-12-01
Description:
Understanding how biochemical pathways are connected in the cell is one of the big challenges facing cell biologists. In a Perspective, von Zastrow and Mostov describe new work that identifies a protein called RGS-PX1 as the linchpin that connects signal transduction activated by G protein-coupled receptors with membrane trafficking events.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉von Zastrow, M -- Mostov, K -- New York, N.Y. -- Science. 2001 Nov 30;294(5548):1845-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Departments of Psychiatry, University of California, San Francisco, CA 94143, USA. zastrow@itsa.ucsf.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11729293" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Arrestins/metabolism
;
Carrier Proteins/chemistry/*metabolism
;
Databases, Genetic
;
GTPase-Activating Proteins/chemistry/*metabolism
;
Heterotrimeric GTP-Binding Proteins/chemistry/*metabolism
;
Humans
;
Protein Binding
;
Protein Structure, Tertiary
;
Protein Transport
;
RGS Proteins/chemistry/*metabolism
;
Receptor, Epidermal Growth Factor/metabolism
;
Signal Transduction
;
Sorting Nexins
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
