Publication Date:
2008-01-12
Description:
Secondary lymphoid organs are dominant sites of T cell activation, although many T cells are subsequently retained within peripheral tissues. Currently, these nonlymphoid compartments are viewed as sites only of effector T cell function, without the involvement of renewed induction of immunity via the interactions with professional antigen-presenting cells. We describe a method of reactivation of herpes simplex virus to examine the stimulation of tissue-resident T cells during secondary challenge. The results revealed that memory CD8+ T cell responses can be initiated within peripheral tissues through a tripartite interaction that includes CD4+ T cells and recruited dendritic cells. These findings lend evidence for the existence of a sophisticated T cell response mechanism in extra-lymphoid tissues that can act to control localized infection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wakim, Linda M -- Waithman, Jason -- van Rooijen, Nico -- Heath, William R -- Carbone, Francis R -- New York, N.Y. -- Science. 2008 Jan 11;319(5860):198-202. doi: 10.1126/science.1151869.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria 3010, Australia.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18187654" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigen Presentation
;
CD8-Positive T-Lymphocytes/*immunology
;
Dendritic Cells/*immunology
;
Female
;
Ganglia, Spinal/*immunology/transplantation/virology
;
Herpes Simplex/*immunology/virology
;
Herpesvirus 1, Human/*immunology/physiology
;
*Immunologic Memory
;
*Lymphocyte Activation
;
Lymphocyte Count
;
Male
;
Mice
;
Mice, Inbred C57BL
;
Mice, Knockout
;
Mice, Transgenic
;
T-Lymphocyte Subsets/immunology
;
T-Lymphocytes, Helper-Inducer/immunology
;
Viral Envelope Proteins/immunology
;
Virus Activation
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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