ISSN:
1741-0444
Keywords:
Activated fibres' territory
;
Desynchronisation
;
Extracellular potential amplitude
;
Extracellular potential integral
;
Fibre-electrode distance
;
Fibre excitation parameters
;
Inverse problem
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
Notes:
Abstract The possibility of solving the inverse problem in electroneurography, i.e. of estimating the main parameters specifying the activated fibre's functional state, using the amplitude and integral characteristics of the surface potentials generated by infinite homogeneous fibres, has been analysed. An analytical expression has been found for the amplitude of the negative phase Anph of the single fibre extracellular action potential (SFEAP) as a function of the wavelength b, the fibre-electrode distance y and a scale factor Ao proportional to the intracellular action potential amplitude Vm, to the square of the fibre radius a and to the ratio of the axoplasm conductivity τa and volume conductor conductivity τe. For a large fibre-electrode distance, typical of surface recordings, an analytical expression of the integral of the negative phase Inph of the SFEAP as a function of Ao, b, y and the propagation velocity v was also found. Simple methods are proposed for estimating v, the location of the electrical centre of the activated fibres' territory and the product of the number of activated fibres N, duration Tin of the intracellular action, potential and of the factor Ao. The estimation errors due to the temporal and spatial dispersion of the activated fibres were analysed as a function of the fibre-electrode distance and the territory shape.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02446975
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