Publication Date:
2010-11-26
Description:
Metacaspases are distant relatives of animal caspases found in protozoa, fungi, and plants. Limited experimental data exist defining their function(s), despite their discovery by homology modeling a decade ago. We demonstrated that two type I metacaspases, AtMC1 and AtMC2, antagonistically control programmed cell death in Arabidopsis. AtMC1 is a positive regulator of cell death and requires conserved caspase-like putative catalytic residues for its function. AtMC2 negatively regulates cell death. This function is independent of the putative catalytic residues. Manipulation of the Arabidopsis type I metacaspase regulatory module can nearly eliminate the hypersensitive cell death response (HR) activated by plant intracellular immune receptors. This does not lead to enhanced pathogen proliferation, decoupling HR from restriction of pathogen growth.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Coll, Nuria S -- Vercammen, Dominique -- Smidler, Andrea -- Clover, Charles -- Van Breusegem, Frank -- Dangl, Jeffery L -- Epple, Petra -- R01 GM057171/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2010 Dec 3;330(6009):1393-7. doi: 10.1126/science.1194980. Epub 2010 Nov 18.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, 108 Coker Hall, University of North Carolina (UNC), CB 3280, Chapel Hill, NC 27599-3280, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21097903" target="_blank"〉PubMed〈/a〉
Keywords:
*Apoptosis
;
Arabidopsis/*enzymology/immunology/microbiology/*physiology
;
Arabidopsis Proteins/chemistry/genetics/*metabolism
;
Caspases/chemistry/genetics/*metabolism
;
DNA-Binding Proteins/chemistry/genetics/metabolism
;
Mutation
;
Oomycetes/physiology
;
Plant Diseases/immunology/microbiology
;
Plants, Genetically Modified
;
Pseudomonas syringae/physiology
;
Transcription Factors/chemistry/genetics/metabolism
;
Zinc Fingers
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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